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||Bcl-10 is an intracellular signaling protein identified from the t (p22;q32) breakpoint in MALT lymphomas. The human Bcl-10 gene encodes a protein of 233 amino acids containing an N-terminal Caspase Recruitment Domain (CARD) that mediates self-oligomerization and the Cterminal region of Bcl-10. Bcl-10 is expressed ubiquitously with highexpression levels in lymphoid tissues and in the developing central nerve system. Mutations have been found in cases of follicular lymphoma and diffuse large B cell lymphoma. Bcl-10 is a positive regulator of antigenreceptor induced NF-B activation and Bcl-10-initiated activation of NF-B can be inhibited by cotransfection of dominant-negative mutants of TRAF2, NIK, IKKa or IkBa. The wild type human Bcl-10 protein was expressed in baculovirus system and purified by an affinity column in combination with FPLC chromatography. Purified protein is greater than 95% homogeneous and contains no detectable proteases, DNase, and RNase activity.
||Sf9 insect cells.
||Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 100 mM KCl, 0.2 mM EDTA, 1 mM DTT and 20% glycerol.
||> 95% by SDS-PAGE.
||100 ng are required for a protein-protein interaction assay.
||Recombinant Bcl-10 protein can be used for 1) protein-protein interaction assay 2) for in vitro transcription assay 3) for cell growth assay.
||For in vitro use only.
||Quality guaranteed for 12 months store at -80°C Avoid freeze / thaw cycles