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Active Recombinant Human Estrogen Receptor 1

Cat.No. : ESR1-1033H
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Cat. No. : ESR1-1033H
Description : Recombinant His tagged ER was expressed in a baculovirus system and purified by an affinity column in combination with FPLC chromatography. Several members of nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; Estrogen Receptoralpha (ER) in breast cancer, Androgen Receptor (AR) in prostate cancer, and Retinoic Acid Receptor alpha (RAR) in acute promyelocytic leukemia. Estrogen receptors (ER) are members of the superfamily of nuclear hormone receptors whose activity is required for the normal function of the female reproductive system. Two isoforms of Estrogen Receptor (ER and ER) have been described. They function as ligand-dependent transcriptional activators. The biological functions downstream of ER result from altered expression of direct transcriptional targets as well as secondary effects mediated by biological activities of direct targets. In the mammary gland, estrogen receptors regulate normal epithelial cell development and differentiation through their well-documented effects on transcription. Estrogens have long been known to have mitogenic functions in breast cancer cell lines and in breast tumors. Selective Estrogen Receptor Modulatory compounds (SERMs), which bind directly to ER, can block the growth stimulatory function of estrogens.
Source : Sf9 insect cells.
Application : ER has been applied in DNA and protein-protein interaction assays.
Usage : For in vitro use only.
Form : Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 100 mM KCl, 0.2 mM EDTA, 1 mM DTT and 20% glycerol.
Activity : 20-100 ng are sufficient for an in vitro transcription assay and 100 ng are sufficient for a protein-protein interactions assay.
Purity : > 95% by SDS-PAGE.
Storage : Quality guaranteed for 12 months, Store at -80°C. Avoid freeze / thaw cycles.
Publication :
Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression (2018)
Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α (2020)
Gene Name : ESR1 estrogen receptor 1 [ Homo sapiens ]
Synonyms : ESR1; estrogen receptor 1; ER; ESR; Era; ESRA; NR3A1; DKFZp686N23123; Estrogen receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1
Gene ID : 2099
mRNA Refseq : NM_000125
Protein Refseq : NP_000116
MIM : 133430
UniProt ID : P03372
Chromosome Location : 6q24-q27
Function : estrogen receptor activity; estrogen response element binding; hormone binding; metal ion binding; nitric-oxide synthase regulator activity; protein N-terminus binding; sequence-specific DNA binding; steroid binding; transcription factor activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What are the clinical implications of ESR1 mutations in breast cancer? 04/13/2023

ESR1 mutations can lead to resistance to endocrine therapies in breast cancer patients, impacting treatment outcomes.

How does ESR1 testing impact the prognosis of breast cancer patients? 10/02/2022

ESR1 testing can provide important prognostic information by helping to predict the likelihood of a favorable response to hormone therapy.

How is ESR1 protein detected in clinical practice? 09/27/2021

ESR1 protein can be detected through various laboratory techniques, including immunohistochemistry (IHC) and immunoblotting.

Can ESR1 mutations be targeted in breast cancer treatment? 02/23/2021

Research is ongoing, and there are efforts to develop targeted therapies for ESR1-mutated breast cancer, but it's still an evolving field.

How is ESR1 status determined in breast cancer patients? 05/05/2019

ESR1 status is determined through the examination of tumor tissue samples, often using IHC or molecular testing.

Customer Reviews (3)

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Reviews
05/30/2021

    Its high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.

    04/24/2019

      Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.

      12/08/2017

        With the ESR1 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.

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