Pyridoxal kinase


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Pyridoxal kinase

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Cat. No. : CBCRY19
Background : Pyridoxal kinase, a member of the ribokinase superfamily, catalyzes the ATP-dependent phosphorylation reaction of vitamin B6 and is an essential enzyme in the formation of pyridoxal-5"-phosphate, a key cofactor for over 100 enzymes. Pyridoxal kinase is thus regarded as a potential target for pharmacological agents. Structure comparison reveals that the key 12-residue peptide over the active site in HPLK is a beta-strand/loop/beta-strand flap, while the corresponding peptide in sheep brain enzyme adopts a loop conformation. Moreover, HPLK possesses a more hydrophobic ATP-binding pocket.
Protein Classification : Transferase
Structure Weight : 74135.20 Da
Polymer : 1
Molecule : Pyridoxal kinase
Chain Length : 327 amino acids
MMDB ID : 39840
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.8Å
Reference : Cao, P., Gong, Y., Tang, L., Leung, Y.C., Jiang, T.(2006) Crystal structure of human pyridoxal kinaseJ.Struct.Biol.154: 327-332
Gene Name : PDXK
Synonyms : C21orf124; C21orf97; EC; DKFZp566A071; FLJ31940; FLJ37311; FLJ21324; MGC15873; MGC31754; MGC52346; PKH; PNK; PRED79; pyridoxal kinase; pyridoxamine kinase; pyridoxine kinase; vitamin B6 kinase; chromosome 21 open reading reame 124; chromosome 21 open reading frame 97
UniProt ID : O00764
Gene ID : 8566
Chromosome Location : 21q22.3
Function : ATP binding; lithium ion binding; magnesium ion binding; nucleotide binding; potassium ion binding; protein homodimerization activity; pyridoxal kinase activity; sodium ion binding; transferase activity; zinc ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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