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Recombinant Guinea Pig Histamine Receptor H 2

Cat. No.: Hrh2-1043G
Description: The histamine H2-receptor (H2R) belongs to the superfamily of seven transmembrane domain (7TM), G-protein-coupled receptors (GPCRs). The endogenous agonist for the H2R is histamine which is both neurotransmitter and autacoid.The H2Rcouples to Gs-proteinsto mediate adenylate cyclase (AC) activation. In some systems, the H2R also couples to Gq-proteins and phospholipase C. Among the many responses mediated by the H2R are gastric acid secretion, smooth muscle relaxation, positive ionotropic and chronotropic effects on heart muscle, and inhibition of leukocyte function. The guinea pig H2R (gp H2R) was prepared from Sf9 cells infected with gp H2R -encoding baculovirus. In this system, gp H2R couples to the Gs-like G-proteins of the insect cells to mediate AC activation. gp H2R contains a N-terminal FLAG-tag and a Cterminal hexahistidine (His6)-tag for immunological detection, to allow purification, and to provide additional protection against proteolysis.
Source: Sf9 insect cells.
Form: Membrane suspension. Supplied in 75 mM Tris-HCl, pH 7.4, 12.5 mM MgCl2and 1 mM EDTA.
Usage: For in vitro use only.
Storage: Quality guaranteed for 12 months. Store at -80°C. Avoid freeze / thaw cycles.
Gene Name: Hrh2 histamine receptor H 1 [ Cavia porcellus ]
Synonyms: Hrh2; histamine receptor H 2; histamine H2 receptor
Gene ID: 100135540
UniProt ID: P47747

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