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Recombinant Human Histamine Receptor H 2

Cat. No. : HRH2-1047H
Description : The histamine H2-receptor (H2R) belongs to the superfamily of seven transmembrane domain (7TM), G-protein-coupled receptors (GPCRs). The endogenous agonist for the H2R is histamine which is both neurotransmitter and autacoid.The H2R couples to Gs-proteins to mediate adenylate cyclase (AC) activation. In some systems, the H2R also couples to Gq-proteins and phospholipase C. Among the many responses mediated by the H2R are gastric acid secretion, smooth muscle relaxation, positive ionotropic and chronotropic effects on heart muscle, and inhibition of leukocyte function. The guinea pig H2R (gp H2R) was prepared fromSf9 cellsinfected with gp H2R -encoding baculovirus. In this system, gp H2R couples to the Gs-like G-proteins of the insect cells to mediate AC activation. gp H2R contains a N-terminal FLAG-tag and a Cterminal hexahistidine (His6)-tag for immunological detection, to allow purification, and to provide additional protection against proteolysis.
Source : Sf9 insect cells.
Form : Membrane suspension. Supplied in 75 mM, Tris-HCl pH 7.4, 12.5 mM MgCl2and 1 mM EDTA.
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months. Store at -80°C. Avoid freeze / thaw cycles.
Gene Name : HRH2 histamine receptor H 1 [ Cavia porcellus ]
Synonyms : HRH2; histamine receptor H 2; Histamine H2 receptor; Gastric receptor I; gastric receptor 1; DBP1; DDX15; DHX15; H2R
Gene ID : 3274
mRNA Refseq : NM_001131055
Protein Refseq : NP_001124527
MIM : 142703
UniProt ID : P25021
Chromosome Location : 5q35
Pathway : Calcium signaling pathway; Neuroactive ligand-receptor interaction; Signaling by GPCR
Function : G-protein coupled receptor activity; histamine receptor activity; receptor activity

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