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Recombinant Human Jun Oncogene

Cat. No.: JUN-1027H
Description: C-Jun is the name of a gene and protein which, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. C-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated (termed c-JunAA) can survive.The growth- promoting activity of c-jun is mediated by repression of tumor suppressors, as well as up-regulation of positive cell cycle regulators. Mostly, c-jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. Recombinant c-jun was expressed in aBaculovirussystem and purified by an affinity column in combination with FPLC chromatography. The purified recombinant protein contains no detectable protease, DNase, and RNase activity.
Source: Baculovirus.
Form: Liquid. Supplied in 20mM Tris-HCl pH8.0, 20% glycerol, 100mM KCl, 0.2mM EDTA and 1mM DTT.
Activity: 100ng are sufficient for a protein-protein interaction assay.
Application: C-fos has been applied in protein-DNA and protein-protein interaction assays.
Purity: >90% by SDS-PAGE.
Usage: For in vitro use only.
Storage: Quality guaranteed for 12 months. Store at -80°C. Avoid freeze / thaw cycles.
Gene Name: JUN jun oncogene [ Homo sapiens ]
Synonyms: JUN; jun oncogene; AP1; AP-1; c-Jun; activator protein 1; enhancer-binding protein AP1; Jun activation domain binding protein; v-jun sarcoma virus 17 oncogene homolog; v-jun avian sarcoma virus 17 oncogene homolog
Gene ID: 3725
mRNA Refseq: NM_002228
Protein Refseq: NP_002219
MIM: 165160
UniProt ID: P05412
Chromosome Location: 1p32-p31
Pathway: B cell receptor signaling pathway; Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; ErbB signaling pathway; Focal adhesion; GnRH signaling pathway; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Renal cell carcinoma; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Wnt signaling pathway; Signaling in Immune system
Function: R-SMAD binding; RNA polymerase II transcription factor activity; Rho GTPase activator activity; double-stranded DNA binding; promoter binding; protein dimerization activity; transcription factor activity; transcription factor binding

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