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Recombinant Human LCK, SH3 Domain, GST-tagged

Cat. No.: LCK -174H
Description: N-terminal GST tagged Lck SH3 domain. Human lymphocyte specific kinase (Lck) is involved in Tcelland IL2-receptor signaling. Lck SH3 domain is the SH3 domain of Lck tyrosine kinase. SH3 domains are known to bind proline rich peptides. The Lck SH3 domain has been expressed as a fusion protein with GST allowing expression inE. coliand purification by affinity chromatography. The native GST-Lck-SH3 is the ideal tool for in vitro/in vivo investigations of the behaviour of cellular prions. It may be used for protein-protein interaction studies as well as for in vitro/in vivo conversion studies. The GST-Tag facilitates the protein's application in typical GST pull-down assays.
Source: E. coli.
Purity: > 90% by SDS-PAGE.
Form: Lyophilized.
Storage: Quality guaranteed for 12 months. Store at -20°C.Avoid freeze / thaw cycles.
Usage: For in vitro use only.
Gene Name: LCK lymphocyte-specific protein tyrosine kinase [ Homo sapiens ]
Synonyms: lymphocyte-specific protein tyrosine kinase; YT16; p56lck; pp58lck; LCK; protein tyrosine kinase; protein tyrosine kinase; protein tyrosine kinase; protein tyrosine kinase; EC 2.7.10.2; LSK; p56-LCK;Lymphocyte cell-specific protein-tyrosine kinase; T cell-specific protein-tyrosine kinase
Gene ID: 3932
mRNA Refseq: NM_001042771
Protein Refseq: NP_001036236
MIM: 153390
UniProt ID: P06239
Chromosome Location: 1p34.3
Pathway: Natural killer cell mediated cytotoxicity; Primary immunodeficiency; T cell receptor signaling pathway; HIV Infection; HIV Infection; Signaling in Immune system
Function: non-membrane spanning protein tyrosine kinase activity; ATP binding; ATPase binding; CD4 receptor binding; CD8 receptor binding; SH2 domain binding; glycoprotein binding; nucleotide binding; phosphoinositide 3-kinase binding; protein C-terminus binding; protein kinase binding; protein serine/threonine phosphatase activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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