Recombinant Human LCK, SH3 Domain, GST-tagged LCK-174H

Recombinant Human LCK, SH3 Domain, GST-tagged


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Recombinant Human LCK, SH3 Domain, GST-tagged

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Cat. No. : LCK -174H
Description : N-terminal GST tagged Lck SH3 domain. Human lymphocyte specific kinase (Lck) is involved in Tcelland IL2-receptor signaling. Lck SH3 domain is the SH3 domain of Lck tyrosine kinase. SH3 domains are known to bind proline rich peptides. The Lck SH3 domain has been expressed as a fusion protein with GST allowing expression inE. coliand purification by affinity chromatography. The native GST-Lck-SH3 is the ideal tool for in vitro/in vivo investigations of the behaviour of cellular prions. It may be used for protein-protein interaction studies as well as for in vitro/in vivo conversion studies. The GST-Tag facilitates the protein's application in typical GST pull-down assays.
Source : E. coli.
Purity : > 90% by SDS-PAGE.
Form : Lyophilized.
Storage : Quality guaranteed for 12 months. Store at -20°C.Avoid freeze / thaw cycles.
Usage : For in vitro use only.
The SH2 domain of human Lck colored from blue (N-terminus) to red (C-terminus). :

Gene Name : LCK lymphocyte-specific protein tyrosine kinase [ Homo sapiens ]
Synonyms : lymphocyte-specific protein tyrosine kinase; YT16; p56lck; pp58lck; LCK; protein tyrosine kinase; protein tyrosine kinase; protein tyrosine kinase; protein tyrosine kinase; EC; LSK; p56-LCK;Lymphocyte cell-specific protein-tyrosine kinase; T cell-specific protein-tyrosine kinase
Gene ID : 3932
mRNA Refseq : NM_001042771
Protein Refseq : NP_001036236
MIM : 153390
UniProt ID : P06239
Chromosome Location : 1p34.3
Pathway : Natural killer cell mediated cytotoxicity; Primary immunodeficiency; T cell receptor signaling pathway; HIV Infection; HIV Infection; Signaling in Immune system
Function : non-membrane spanning protein tyrosine kinase activity; ATP binding; ATPase binding; CD4 receptor binding; CD8 receptor binding; SH2 domain binding; glycoprotein binding; nucleotide binding; phosphoinositide 3-kinase binding; protein C-terminus binding; protein kinase binding; protein serine/threonine phosphatase activity; transferase activity

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