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Active Recombinant Human MAP2K6, GST-tagged

Cat.No. : MAP2K6-176H
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Cat. No. : MAP2K6-176H
Description : N-terminal GST-tagged full-length protein. MKK6 is one of the major specific activators of p38. MAP kinase kinases (MAPKKs) MKK3 and MKK6 are the primary regulators of p38 phosphorylation and activation. The MKK6/p38 pathway is well documented in the regulation of apoptosis. The p38 mitogen-activated protein (MAP) kinase signal transduction pathway regulates the production of interleukin-1 and tumor necrosis factor-alpha. The recombinant human MKK6 was expressed inE. coliand purified by glutathione sepharose chromatography. It is suitable for labeling MKK6 substrates. The highly active form is produced by two amino acid exchanges (S151E, T155E). The sequence based calculated molecular weight is 63.64 kDa.
Source : E. coli.
Form : Supplied in 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 1 mM DTT and 270 mM sucrose.
Purity : > 95% by SDS-PAGE.
Activity : > 50,000 U/mg (1 Unit is defined as the amount of MKK6 which activates inactive p38α/SAPK2a (0.5 mg/ml) by 1 U/min using 125 μM ATP at 30 °C. 1 Up38α/SAPK2a activity is defined as 1 picomole phosphate transferred to myelin basic protein per min at 30 °C).
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles.
Gene Name : MAP2K6 mitogen-activated protein kinase kinase 6 [ Homo sapiens ]
Synonyms : MAP2K6; mitogen-activated protein kinase kinase 6; MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); EC 2.7.12.2; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPK/ERK kinase 6
Gene ID : 5608
mRNA Refseq : NM_002758
Protein Refseq : NP_002749
MIM : 601254
UniProt ID : P52564
Chromosome Location : 17q
Pathway : Amyotrophic lateral sclerosis (ALS); Fc epsilon RI signaling pathway; GnRH signaling pathway; MAPK signaling pathway; Toll-like receptor signaling pathway
Function : ATP binding; MAP kinase kinase ; activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is MAP2K6 a potential biomarker for predicting treatment response? 05/02/2022

Its expression levels in certain cancers are being explored as predictive biomarkers to anticipate response to specific therapies.

Is MAP2K6 involved in any other diseases besides cancer? 04/15/2021

Studies also suggest its involvement in cardiovascular diseases and neurological disorders.

How does MAP2K6 relate to drug resistance in cancer treatment? 12/06/2020

MAP2K6 signaling pathways might play a role in drug resistance mechanisms, making it a focus for overcoming therapeutic challenges.

Are there any known diseases associated with MAP2K6 mutations? 11/01/2019

Yes, mutations in MAP2K6 have been linked to certain cancers, including colorectal cancer and lung adenocarcinoma.

Can MAP2K6 inhibition lead to potential side effects? 06/26/2018

As with any targeted therapy, MAP2K6 inhibitors might have side effects, which are under investigation in preclinical and clinical studies.

Customer Reviews (3)

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Reviews
07/21/2022

    I am certain that the MAP2K6 protein will play a pivotal role in facilitating robust and insightful research, providing the assurance of reliable and consistent results.

    03/23/2022

      The excellent technical support provided by the manufacturer can solve my problem.

      12/27/2021

        Whether I am studying protein-protein interactions, investigating cellular pathways, or examining protein folding dynamics, the MAP2K6 protein consistently delivers exceptional performance and precise outcomes.

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