Recombinant Human MAPK14, Active, His-tagged

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Recombinant Human MAPK14, Active, His-tagged

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Cat. No. : MAPK14-177H
Description : p38α/SAPK2a belongs to the family of mitogen-activated protein kinases (MAPK). Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, proteinserine/ threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. p38α/SAPK2a was discovered independently in three contexts. It was found as a tyrosine phosphoprotein present in extracts of cells treated with inflammatory cytokines; as the target of a pyridinyl imidazole drug that blocked production of tumor necrosis factor-α (TNFα) and as such was called cytokine-suppressive anti-inflammatory drug-binding protein or CSBP; and as a reactivating kinase for MAP kinase-activated protein (MAPKAP) kinase- 2. A variety of agents including cytokines, hormones, GPCRs, osmotic and heat shock, and other stresses activate p38 family members. The recombinant human p38αkinase (SAPK2a) was expressed inE. coliand purified by Ni-agarose chromatography.It has a The active form was produced by phosphorylation of the purified p38a with MKK6. It is suitable for labeling p38a kinase substrates. MW = 42.7 kDa.
Source : E. coli.
Form : Supplied in 25 mM Tris-HCl pH 8.5, 150 mM NaCl, 1 mM DTT and 50% glycerol.
Purity : > 95% by SDS-PAGE.
Activity : > 100,000 U/mg (1 Unit is defined as 1 picomole phosphate transferred to myelin basic protein per min at 30°C) N-terminal His-tagged full-length protein.
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles.
PDB rendering based on 1a9u. :

Gene Name : MAPK14 mitogen-activated protein kinase 14 [ Homo sapiens ]
Synonyms : MAPK14; mitogen-activated protein kinase 14; RK; p38; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA; p38 MAP kinase; p38alpha Exip; MAP kinase Mxi2; Csaids binding protein; MAX-interacting protein 2; stress-activated protein kinase 2A; p38 mitogen activated protein kinase; cytokine suppressive anti-inflammatory drug binding protein; EC 2.7.11.24; Mitogen-activated protein kinase p38 alpha; CSAID-binding protein MAP kinase p38 alpha; MAP kinase MXI2; CSBP; MXI2
Gene ID : 1432
mRNA Refseq : NM_001315
Protein Refseq : NP_001306
MIM : 600289
UniProt ID : Q16539
Chromosome Location : 6p21.3-p21.2
Pathway : Amyotrophic lateral sclerosis (ALS); Epithelial cell signaling in Helicobacter pylori infection; Fc epsilon RI signaling pathway; GnRH signaling pathway; Leukocyte transendothelial migration; MAPK signaling pathway; Neurotrophin signaling pathway; RIG-I-like receptor signaling pathway; T cell receptor signaling pathway; Toll-like receptor signaling pathway; VEGF signaling pathway; Signalling by NGF
Function : ATP binding; MAP kinase activity; MAP kinase kinase activity; MP kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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