Androgen Receptor


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Androgen Receptor

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Cat. No. : CBCRY23
Background : Androgen receptor (AR) is a ligand-inducible steroid hormone receptor that mediates androgen action, determining male sexual phenotypes and promoting spermatogenesis. As the androgens play a dominant role in male sexual development and function, steroidal androgen agonists have been used clinically for some years. However, there is a risk of potential side effects and most steroidal androgens cannot be dosed orally, which limits the use of these substances. 1,2-Dihydro-6-N,N-bis(2,2,2-trifluoroethyl)amino-4-trifluoromethyl-2-quinolinone (LGD2226) is a synthetic nonsteroidal ligand and a novel selective AR modulator.
Protein Classification : Ligand Binding Protein
Structure Weight : 29541.62 Da
Polymer : 1
Molecule : Androgen receptor
Chain Length : 250 amino acids
MMDB ID : 53414
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.8Å
Ligand Chemical Component : 6-[Bis(2,2,2-Trifluoroethyl)Amino]-4-(Trifluoromethyl)quinolin-2(1H)-one.
Reference : Wang, F., Liu, X.-Q., Li, H., Liang, K.-N., Miner, J.N., Hong, M., Kallel, E.A., van Oeveren, A., Zhi, L., Jiang, T. (2006) Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226 ACTA CRYSTALLOGR.,SECT.F 62: 1067-1071
Gene Name : AR
Synonyms : RP11-383C12.1; AIS, DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM; OTTHUMP00000023450; OTTHUMP00000061928; dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; spinal and bulbar muscular atrophy
UniProt ID : P10275
Gene ID : 367
Chromosome Location : Xq11.2-q12
Function : androgen binding; androgen receptor activity; metal ion binding; receptor activity; protein dimerization activity; receptor binding; sequence-specific DNA binding; transcription factor activity; zinc ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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