Androgen Receptor
Cat.No. : | CBCRY23 |
- Specification
- Gene Information
- Related Products
Cat. No. : | CBCRY23 |
Background : | Androgen receptor (AR) is a ligand-inducible steroid hormone receptor that mediates androgen action, determining male sexual phenotypes and promoting spermatogenesis. As the androgens play a dominant role in male sexual development and function, steroidal androgen agonists have been used clinically for some years. However, there is a risk of potential side effects and most steroidal androgens cannot be dosed orally, which limits the use of these substances. 1,2-Dihydro-6-N,N-bis(2,2,2-trifluoroethyl)amino-4-trifluoromethyl-2-quinolinone (LGD2226) is a synthetic nonsteroidal ligand and a novel selective AR modulator. |
Protein Classification : | Ligand Binding Protein |
Structure Weight : | 29541.62 Da |
Polymer : | 1 |
Molecule : | Androgen receptor |
Chain Length : | 250 amino acids |
PDB ID : | 2HVC |
MMDB ID : | 53414 |
Source : | E.coli |
Method : | X-Ray Diffraction |
Resolution : | 2.8Å |
Ligand Chemical Component : | 6-[Bis(2,2,2-Trifluoroethyl)Amino]-4-(Trifluoromethyl)quinolin-2(1H)-one. |
Reference : | Wang, F., Liu, X.-Q., Li, H., Liang, K.-N., Miner, J.N., Hong, M., Kallel, E.A., van Oeveren, A., Zhi, L., Jiang, T. (2006) Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226 ACTA CRYSTALLOGR.,SECT.F 62: 1067-1071 |
Gene Name : | AR |
Synonyms : | RP11-383C12.1; AIS, DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM; OTTHUMP00000023450; OTTHUMP00000061928; dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; spinal and bulbar muscular atrophy |
UniProt ID : | P10275 |
Gene ID : | 367 |
Chromosome Location : | Xq11.2-q12 |
Function : | androgen binding; androgen receptor activity; metal ion binding; receptor activity; protein dimerization activity; receptor binding; sequence-specific DNA binding; transcription factor activity; zinc ion binding |
Products Types
◆ Lysates | ||
AR-8764HCL | Recombinant Human AR 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1654 | CHO-K1 AR Protein Interaction Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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