Recombinant Human Granulin, His-tagged
Cat.No. : | GRN-113H |
Product Overview : | Recombinant Human granulin encoding the human Pro-Granulins(Thr18-Leu593) was expressed inE.coli. It was recombined with a Hexa-his sequence of pET-28a vector at the N-Terminusand purified by Ni-NTA column. MW= 63.4 KD. |
- Specification
- Gene Information
- Related Products
Cat. No. : | GRN-113H |
Description : | Granulin is a protein that in humans is encoded by the GRN gene.Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. |
Sequence : | Human Pro-Granulins (Thr18-Leu593)18 TRCPDGQFCP VACCLDPGGA SYSCCRPLLD KWPTTLSRHL GGPCQVDAHC SAGHSCIFTV SGTSSCCPFP EAVACGDGHH CCPRGFHCSA DGRSCFQRSG NNSVGAIQCP DSQFECPDFS TCCVMVDGSW GCCPMPQASC CEDRVHCCPH GAFCDLVHTR CITPTGTHPL AKKLPAQRTN RAVALSSSVM CPDARSRCPD GSTCCELPSG KYGCCPMPNA TCCSDHLHCC PQDTVCDLIQ SKCLSKENAT TDLLTKLPAH TVGDVKCDME VSCPDGYTCC RLQSGAWGCC PFTQAVCCED HIHCCPAGFT CDTQKGTCEQ GPHQVPWMEK APAHLSLPDP QALKRDVPCD NVSSCPSSDT CCQLTSGEWG CCPIPEAVCC SDHQHCCPQG YTCVAEGQCQ RGSEIVAGLE KMPARRASLS HPRDIGCDQH TSCPVGQTCC PSLGGSWACC QLPHAVCCED RQHCCPAGYT CNVKARSCEK EVVSAQPATF LARSPHVGVK DVECGEGHFC HDNQTCCRDN RQGWACCPYR QGVCCADRRH CCPAGFRCAA RGTKCLRREA PRWDAPLRDP ALRQLL 593 |
Source : | E.coli. |
Formulation : | Lyophilized 100μg human GRN in 50μl of TBS (20mM Tris, 50mM NaCl, pH8.0). Carry free. |
Purity : | >95% by SDS gel. |
Application : | Cell biology. |
Reconstitution : | Add 500μl deionized water to the vial to prepare a working stock solution at 200μg/mL. Allow to set at least 30 minutes at 4℃, mix well. |
Storage : | Store lyophilized protein at -20℃ or -70℃. Lyophilized protein is stable for up to 6 months from date of receipt at -20℃ to -70℃. Upon reconstitution, this protein can be stored at -20℃ for a few weeks or at -70℃ in a manual defrost freezer for long term storage (six months). Aliquot reconstituted protein to avoid repeated freezing / thawing cycles. |
Gene Name : | GRN granulin [ Homo sapiens ] |
Synonyms : | GRN; granulin; GEP; GP88; PEPI; PGRN; PCDGF; progranulin; Granulins; Proepithelin; Acrogranin; Paragranulin; Granulin-1; Granulin G; Granulin-2; Granulin F; Granulin-3; Granulin B; Granulin-4; Granulin A; Granulin-5; Granulin C; Granulin-6; Granulin D; Granulin-7; Granulin E; PC cell-derived growth factor; granulin-epithelin |
Gene ID : | 2896 |
mRNA Refseq : | NM_002087 |
Protein Refseq : | NP_002078 |
MIM : | 138945 |
UniProt ID : | P28799 |
Chromosome Location : | 17q21.32 |
Function : | cytokine activity; growth factor activity |
Products Types
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GRN-5375H | Recombinant Human GRN Protein, GST-tagged | +Inquiry |
Grn-1065M | Recombinant Mouse Grn Protein, MYC/DDK-tagged | +Inquiry |
GRN-1022H | Recombinant Human GRN Protein, His (Fc)-Avi-tagged | +Inquiry |
GRN-041H | Recombinant Human GRN Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
GRN-2358H | Recombinant Human GRN Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
GRN-2791HCL | Recombinant Human GRN cell lysate | +Inquiry |
GRN-2412MCL | Recombinant Mouse GRN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere is an interaction between GRN protein and TDP-43 protein, and together they are involved in the development of neurodegenerative diseases.
GRN protein is involved in neuroprotection by regulating cell survival, apoptosis, inflammatory response and other pathways. It may work by promoting neuronal survival, suppressing inflammatory responses, and more.
Abnormal expression of GRN protein is related to neurodegenerative diseases, and detecting the expression level of GRN protein or gene mutation can help diagnose these diseases and provide reference for treatment and prognosis assessment.
The role of GRN protein in Alzheimer's disease is not fully understood, but studies have shown that it is involved in the metabolism and clearance of β-amyloid, which may have an important impact on the pathological process.
Yes, some transcription factors have been found to regulate the expression of GRN proteins, including CREB, SMAD, etc.
GRN protein plays an important role in prefrontal dementia. It is involved in the survival and maintenance of nerve cells, and its deletion or mutation may lead to degenerative loss of nerve cells.
Customer Reviews (3)
Write a reviewThe outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.
Application of this protein enables researchers to conduct research in more fields and broadens the horizon of scientific research.
This protein has a short half-life, high clearance rate, and high safety and efficacy.
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