Active Recombinant Human Dual Specificity Phosphatase 3
Cat.No. : | DUSP3-1207H |
- Specification
- Gene Information
- Related Products
Cat. No. : | DUSP3-1207H |
Description : | The mammalian dual-specificity protein-tyrosine phosphatase VHR (for VH1-related) has been identified as a novel regulator of extracellular regulated kinases (ERKs). Vaccinia Virus VH1-related Phosphatase (VHR), also known as Dual-Specificity Phosphatase 3 (DUSP3), removes phosphate groups from tyrosine, serine, and threonine residues. It belongs to a family of phosphatases that selectively dephosphorylate MAP kinases. VHR has been shown to act as a phosphatase for several members of the MAP kinase family including ERK1, ERK2, and JNK. It is a target for the ZAP-70 kinase, and phosphorylation of VHR at tyrosine 138 leads to a downregulation of ERK2 activity. Its welldefined biochemistry has made VHR useful in screening assays for compounds that inhibit phosphatases. |
Source : | E. coli. |
Form : | Liquid. Supplied in 50 mM HEPES pH 7.4, 40 mM NaCl, 1 mM EDTA and 1 mM DTT. |
Purity : | ≥90% by SDS-PAGE. |
Activity : | 1 nmol of Cdc25A will hydrolyze 180 nmol of pNPP per minute at 37°C at pH 6.5. |
Usage : | For in vitro use only. |
Storage : | Quality guaranteed for 12 months store at - 80°C. Avoid freeze / thaw cycles. |
Gene Name : | DUSP3 dual specificity phosphatase 3 [ Homo sapiens ] |
Synonyms : | DUSP3; dual specificity phosphatase 3; VHR; vaccinia virus phosphatase VH1-related; Dual specificity protein phosphatase 3; EC=3.1.3.48; EC=3.1.3.16; Dual specificity protein phosphatase VHR; serine/threonine specific protein phosphatase; vaccinia virus phosphatase VH1-related |
Gene ID : | 1845 |
mRNA Refseq : | NM_004090 |
Protein Refseq : | NP_004081 |
MIM : | 600183 |
UniProt ID : | P51452 |
Chromosome Location : | 17q21 |
Pathway : | MAPK signaling pathway; Signalling by NGF |
Function : | hydrolase activity, protein tyrosine; phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity |
Products Types
◆ Recombinant Protein | ||
DUSP3-3217H | Active Recombinant Human DUSP3 protein(Met1-Pro185) | +Inquiry |
DUSP3-2781H | Recombinant Human DUSP3 Protein, MYC/DDK-tagged | +Inquiry |
DUSP3-1180R | Recombinant Rhesus Macaque DUSP3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Dusp3-2689M | Recombinant Mouse Dusp3 Protein, Myc/DDK-tagged | +Inquiry |
DUSP3-2939H | Recombinant Human DUSP3 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
DUSP3-001HCL | Recombinant Human DUSP3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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