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Hrh2; Histamine receptor H 2; H2R; Histamine H2 receptor

Cat. No.: Hrh2-1143R
Description: The histamine H2-receptor (H2R) belongs to the superfamily of seven transmembrane domain (7TM), G-protein-coupled receptors (GPCRs). The endogenous agonist for the H2R is histamine which is both neurotransmitter and autacoid. The H2R couples to Gs-proteins to mediate adenylate cyclase (AC) activation. In some systems, the H2R also couples to Gq-proteins and phospholipase C. Among the many responses mediated by the H2R are gastric acid secretion, smooth muscle relaxation, positive ionotropic and chronotropic effects on heart muscle, and inhibition of leukocyte function. The rat H2R was prepared from Sf9 cells infected with rat H2R-encodingbaculovirus. In this system, the rat H2R couples to the Gs-like G-proteins of the insect cells to mediate AC activation.
Source: Sf9 insect cells.
Usage: For in vitro use only.
Form: Membrane suspension. Supplied in 75 mM Tris-HCl pH 7.4, 12.5 mM MgCl2 and 1 mM EDTA.
Purity: > 95% by SDS-PAGE.
Storage: Quality guaranteed for 12 months, Store at -80℃. Avoid freeze / thaw cycles.
Gene Name: Hrh2 histamine receptor H 2 [ Rattus norvegicus ]
Synonyms: Hrh2; histamine receptor H 2; H2R; Histamine H2 receptor
Gene ID: 25461
mRNA Refseq: NM_012965
Protein Refseq: NP_037097
UniProt ID: P25102

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