||Rab18A is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. Rab18A is localized in dense apical tubules (kidney) and basolateral membrane (intestine) as well as lipid droplets in ER and neuroendocrine secretory granules. The enzyme is involved in the formation of lipid droplets form ER. Furthermore it is a negative regulator of neuroendocrine secretion. The GST-Tag facilitates the protein's application in typical GST pull-down assays.
||For in vitro use only.
||Liquid. Supplied in 50 mM Tris-HCl, pH 8.0, 100 mM NaCl, 10 mM MgCl2, 10 μM GDP, and 2 mM mercaptoethanol.
||100 pmol of protein can bind > 80 pmol of GDP.
||> 90% by SDS-PAGE.
||Quality guaranteed for 12 months, store at -80℃. Avoid freeze / thaw cycles.