"VPS29" Related Products


Vacuolar Protein Sorting Protein 29

Cat. No.: CBCRY38
Background: VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment.
Protein Classification: cytoplasmic protein
Structure Weight: 20531.90 Da
Polymer: 1
Molecule: Vacuolar Protein Sorting Protein 29
Chain Length: 182 amino acids
PDB ID: 1W24
MMDB ID: 32322
Source: E.coli
Method: X-Ray Diffraction
Resolution: 2.10Å
Reference: Wang, D., Guo, M., Liang, Z., Fan, J., Zhu, Z., Zang, J., Zhu, Z., Li, X., Teng, M., Niu, L., Dong, Y., Liu, P. (2005) Crystal Structure of Human Vacuolar Protein Sorting Protein 29 Reveals a Phosphodiesterase/Nuclease-Like Fold and Two Protein-Protein Interaction Sites. J.Biol.Chem. 280: 22962
Gene Name: VPS29
Synonyms: DC15; DC7; DKFZp564F0223; FLJ20492; PEP11; retromer protein; vacuolar protein sorting 29; vacuolar sorting protein VPS29/PEP11; x 007 protein; EC; hVPS29; vesicle protein sorting 29
UniProt ID: Q9UBQ0
Gene ID: 51699
Chromosome Location: 12q24
Function: zinc ion binding; hydrolase activity; metal ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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