Recombinant Human Regulator Of Chromosome Condensation 1

• Cat.No.: RCC1-1139H

Specification

• Cat. No.: RCC1-1139H
• Description: RCC1 (Regulator of Chromosome Condensation, α βpropeller chromatin-bound protein) catalyzes guanine nucleotide exchange of the Ras-related nuclear protein Ran. RCC1 is the guanine nucleotide exchange factor (GEF) for Ran which induces exchange between the bound GDP and cellular GTP. Genetic studies have suggested that RCC1 may be involved in sensing the replication state of DNA and controlling the activation of Cdc2/cyclin B protein kinase through Ran. MW = 44.97 kDa.
• Source: E. coli.
• Purity: ≥95% by SDS-PAGE.
• Form: Liquid. Supplied in 20 mM HEPES pH 7.6, 50 mM NaCl and 2 mM DTE.
• Storage: Quality guaranteed for 12 months. Store at -80°C.Avoid freeze / thaw cycles.
• Usage: For in vitro use only.

Gene Information

• Gene Name: RCC1 regulator of chromosome condensation 1 [ Homo sapiens ]
• Synonyms: regulator of chromosome condensation 1; CHC1; RCC1-I; RCC1; OTTHUMP00000003775; chromosome condensation 1; guanine nucleotide-releasing protein; HERC2; SHEP1 ; OTTHUMP00000003775; OTTHUMP00000003776; OTTHUMP00000003777; Cell cycle regulatory protein; Chromosome condensation protein 1
• Gene ID: 1104
• mRNA Refseq: NM_001048194
• Protein Refseq: NP_001041659
• MIM: 179710
• UniProt ID: P18754
• Chromosome Location: 1p35.3
• Function: Ran guanyl-nucleotide exchange factor activity; chromatin binding; guanyl-nucleotide exchange factor activity; histone binding