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Recombinant Human Retinoid X Receptor, Beta, GST-tagged

Cat. No. : RXRB-1154H
Description : Retinoid X Receptor (RXR) serves as a promiscuous heterodimerization partner for many nuclear receptors through the identity box, a 40-amino acid subregion within the ligand binding domain. The human RXRβ, gene has been mapped to the short arm or centromeric region of chromosome 6 (6pter-q13) which also contains the MHC I locus. Two major RXRβ isoforms in the mouse, designated RXRβ1 and RXRβ2 (GenBank accession numbers D21830 and D21831), differ in the N-terminal (A) domain with RXRβ 1 containing an extra 72 amino acids. These isoform mRNAs are transcribed from two CpG island promoters and the different N-terminal exons are spliced to exons common to both isoforms from the remainder of the gene. Although the two mouse RXR isoforms have been characterized in some detail, less information is available about their human counterparts. Since the expression of different RXR isoforms appears to be well conserved between species, each receptor isoform may hold a specific role in retinoid signalling. However, many RXR expression studies have not recognised the importance of establishing which RXR isoforms are expressed in a particular system. RXRβ is predominantly involved in retinoid responses in the N-type SH SY 5Y and the S-type SH S EP neuroblastoma cells, both derivatives of a mixed phenotype neuroblastoma cell line. Recombinant GST-RXR is isolated from an E.coli strain that carries the coding sequence of the human RXRβ under the control of a T7 promoter.
Source : E.coli.
Form : Liquid. Supplied in 20mM Tris-HCl pH8.0, 100mM KCl, 0.2mM EDTA, 1mM DTT and 20% glycerol.
Activity : 100ng are sufficient for a protein-protein interaction assay.
Application : GST-RXRβ has been applied in DNA and protein-protein interactions assays.
Purity : >95% by SDS-PAGE.
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months, store at -80℃. Avoid freeze / thaw cycles.
Gene Name : RXRB retinoid X receptor, beta [ Homo sapiens ]
Synonyms : RXRB; retinoid X receptor, beta; NR2B2; DAUDI6; RCoR-1; MGC1831; H-2RIIBP; MHC class I promoter binding protein; Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2
Gene ID : 6257
mRNA Refseq : NM_021976
Protein Refseq : NP_068811
MIM : 180246
UniProt ID : P28702
Chromosome Location : 6p21.3
Pathway : Adipocytokine signaling pathway; Non-small cell lung cancer; PPAR signaling pathway; Pathways in cancer; Small cell lung cancer; Thyroid cancer
Function : ligand-regulated transcription factor activity; metal ion binding; retinoid-X receptor activity; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; zinc ion binding

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