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Recombinant HumanFOSB,GST-tagged,113-151aa

Cat. No.: FOSB-1303H
Prouduct overview: Recombinant Human FOSB (a.a. 113-151) expressed inE.colishows a 32 kDa SDS-PAGE (Including GST). The FOS-B is purified by proprietary chromatographic techniques.
Description: Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos- B include Fra-1 and Fra-2 genes. The 4 members of Fos gene family are: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins which can dimerize with proteins of the JUN family, thus forming the transcription factor complex AP-1. The FOS proteins act as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms exist for Fos B.
Source: Escherichia Coli.
Stability: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Gene Name: FOSB FBJ murine osteosarcoma viral oncogene homolog B[ Homo sapiens ]
Synonyms: FOSB; FBJ murine osteosarcoma viral oncogene homolog B; AP-1; G0S3; GOS3; GOSB; MGC42291; DKFZp686C0818; oncogene FOS-B; activator protein 1; activator protein 1; Protein fosB; G0/G1 switch regulatory protein 3
Gene ID: 2354
mRNA Refseq: NM_001114171
Protein Refseq: NP_001107643
MIM: 164772
UniProt ID: P53539
Chromosome Location: 19q13.3
Function: protein dimerization activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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