|Prouduct overview:||Recombinant Human FOSB (a.a. 113-151) expressed inE.colishows a 32 kDa SDS-PAGE (Including GST). The FOS-B is purified by proprietary chromatographic techniques.|
|Description:||Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos- B include Fra-1 and Fra-2 genes. The 4 members of Fos gene family are: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins which can dimerize with proteins of the JUN family, thus forming the transcription factor complex AP-1. The FOS proteins act as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms exist for Fos B.|
|Stability:||Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.|
|Gene Name:||FOSB FBJ murine osteosarcoma viral oncogene homolog B[ Homo sapiens ]|
|Synonyms:||FOSB; FBJ murine osteosarcoma viral oncogene homolog B; AP-1; G0S3; GOS3; GOSB; MGC42291; DKFZp686C0818; oncogene FOS-B; activator protein 1; activator protein 1; Protein fosB; G0/G1 switch regulatory protein 3|
|Function:||protein dimerization activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding|
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