Recombinant Human FYN Oncogene Related To SRC, FGR, YES FYN-217H

Recombinant Human FYN Oncogene Related To SRC, FGR, YES

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Recombinant Human FYN Oncogene Related To SRC, FGR, YES

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Cat. No. : FYN-217H
Product Overview : Recombinant Human FYN was expressed in E.coli, MW=50 kDa.
Description : p59-Fyn is a member of the protein-tyrosine kinase oncogene family. p59fyn is a membrane-associated non-receptor protein tyrosine kinase that belongs to the Src-family of kinases. p59-Fyn encodes a membrane-associated tyrosine kinase which is implicated in the control of cell growth. p59-Fyn associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. The unique N-terminal domain of p59fyn interacts with the CD3 and eta chains of the TcR. p59fyn can bind other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of fyn activity. p59fyn is highly expressed in brain suggesting that it may have a role in the sensory nervous network and in myelination at early stages of CNS formation. Distinct isoforms exist due to alternative splicing.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered clear solution.
Formulation : p59-Fyn at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Applications : ELISA • Inhibition Assays • Western Blotting.
Purity : Proprietary chromatographic techniques and SDS-PAGE.
Stability : Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
PDB rendering based on 1a0n. :

Gene Name : FYN FYN oncogene related to SRC, FGR, YES [ Homo sapiens ]
Synonyms : FYN; FYN oncogene related to SRC, FGR, YES; SLK; SYN; MGC45350; src-like kinase; OTTHUMP00000017917; c-syn protooncogene; src/yes-related novel; tyrosine kinase p59fyn(T); protein-tyrosine kinase fyn; OKT3-induced calcium influx regulator; Proto-oncogene tyrosine-protein kinase Fyn; EC 2.7.10.2; p59-Fyn; Protooncogene Syn; OTTHUMP00000017914; OTTHUMP00000017915
Gene ID : 2534
mRNA Refseq : NM_002037
Protein Refseq : NP_002028
MIM : 137025
UniProt ID : P06241
Chromosome Location : 6q21
Pathway : Adherens junction; Axon guidance; Fc epsilon RI signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Prion diseases; T cell receptor signaling pathway; Axon guidance; HIV Infection; Hemostasis; Signaling in Immune system
Function : ATP binding; glycoprotein binding; identical protein binding; manganese ion binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; transferase activity; tubulin binding

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