Recombinant Human T-cell Leukemia/lymphoma 1A

• Cat.No.: TCL1A-1404H
• Product Overview: Recombinant Human TCL1A protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 13.4 kDa (114aa).

Specification

• Cat. No.: TCL1A-1404H
• Description: TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism.
• Source: E.coli.
• Amino Acid Sequence: MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD
• Form: Liquid. In 50mM Tris-HCl buffer (pH7.5) containing 10% glycerol.
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: TCL1A T-cell leukemia/lymphoma 1A [ Homo sapiens ]
• Synonyms: TCL1A; T-cell leukemia/lymphoma 1A; TCL1; T-cell lymphoma-1; T-cell lymphoma-1A; TCL-1; Oncogene TCL1; Protein p14 TCL1
• Gene ID: 8115
• mRNA Refseq: NM_001098725
• Protein Refseq: NP_001092195
• MIM: 186960
• UniProt ID: P56279
• Chromosome Location: 14q32.1
• Function: protein binding