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Recombinant Canine Clusterin, Flag-tagged

Cat.No. : CLU-1319C
Product Overview : Recombinant Canine Apoliprotein-J produced inHEK293is a single, non-glycosylated, Polypeptide chain containing436 amino acids and having a molecular mass of 50.72 kDa. The protein is fused with 13 amino acid Flag tag at N-Terminus. The Apoliprotein-J Canine is purified by proprietary chromatographic techniques.
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Cat. No. : CLU-1319C
Description : Clusterin mRNA and Clusterin protein are shown to increase with androgen treatment. Binding of clusterin to the LDL-Receptor plays a role in the pathogenesis of membranous glomerulonephritis. Clusterin is down regulated in CaP in association with matched benign controls. Clusterin is involved in cellular senescence and tumorigenesis. Clusterin is involved in photo-oxidative cell death pathway. Clusterin is a functional tumor marker for the diagnosis of pediatric large cell lymphoma. Clusterin is activated in low pH. Clusterin is involved in the inhibition of NF-kappaB signaling through stabilization of IkappaBs thus results in suppression of tumor cell motility. N-terminal deletion of clusterin is vital for its alterations of biogenesis in esophageal squamous cell carcinoma.
Source : Human Embryonic Kidney 293 Cells.
Amino Acid Sequence : PGDYKDDDDK PAGDQAVSDT ELQEMSTEGS KYINKEIKNA LKGVKQIKTL IEQTNEERKS LLSNLEEAKK KKEDALNDTK DSETKLKASQ GVCNDTMMAL WEECKPCLKQ TCMKFYARVC RSGSGLVGHQ LEEFLNQSSP FYFWMNGDRI DSLLENDRQQ THALDVMQDS FNRASSIMDE LFQDRFFTRE PQDTYHYSPF SLFQRRPFFN PKFRIARNII PFPRFQPLNF HDMFQPFFDM IHQAQQAMDV NLHRIPYHFP IEFPEEDNRT VCKEIRHNST GCLKMKDQCE KCQEILSVDC SSNNPAQVQL RQELSNSLQI AEKFTKLYDE LLQSYQEKMF NTSSLLKQLN EQFSWVSQLA NLTQSEDPFY LQVTTVGSQT SDSNVPVGFT KVVVKLFDSD PITVMIPEAV SRNNPKFMET VAEKALQEYRQKHREE
Purity : Greater than 95% as determined by SDS PAGE.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation : Canine Clusterin was lyophilized from 0.5mg/ml solution containing 20mM Tris buffer and 20mM NaCl,pH7.5
Solubility : Add deionized H2O to a working volume of 0.5mg/ml and let the lyophilized pellet dissolve completely.
Applications : ELISA, Western Blot.
Stability : Store lyophilized protein at -20℃. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4℃ for a limited period of time; it does not show any change after two weeks at 4℃. The lyophilized protein remains stable until the expiry date when stored at -20℃.
Gene Name : CLU clusterin [ Canis lupus familiaris ]
Synonyms : CLU; clusterin; CLU; GP80; glycoprotein 80; lusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
Gene ID : 442971
mRNA Refseq : NM_001003370
Protein Refseq : NP_001003370
UniProt ID : P25473
Chromosome Location : 25

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CLU contribute to the regulation of inflammation, and what role does it play in immune responses and autoimmunity? 05/03/2022

CLU has anti-inflammatory properties and modulates immune responses. Its involvement in autoimmunity is linked to its ability to regulate immune cell functions and cytokine production.

How does CLU contribute to the regulation of cell survival and apoptosis, and what are the molecular mechanisms involved? 03/08/2021

CLU plays a role in regulating cell survival and apoptosis by interacting with key cellular components, including Bcl-2 family members and caspases, modulating apoptotic pathways.

How does CLU influence cell adhesion and migration, and what role does it play in tissue remodeling and repair processes? 01/16/2020

CLU modulates cell adhesion and migration, contributing to tissue remodeling and repair. Its interactions with extracellular matrix components influence cellular behaviors in wound healing and tissue homeostasis.

Can you discuss the association between CLU and neurodegenerative disorders, and how does it impact the pathogenesis of conditions like Alzheimer's disease? 11/16/2019

CLU is implicated in neurodegenerative disorders, particularly Alzheimer's disease. Its involvement in processes such as amyloid-beta aggregation and clearance influences disease progression.

Can you elaborate on the molecular interactions of CLU with lipids and its involvement in lipid transport and metabolism? 07/24/2018

CLU interacts with lipids, participating in lipid transport and metabolism. Its role in lipoprotein remodeling and cholesterol homeostasis links it to cardiovascular health.

Customer Reviews (3)

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Reviews
11/30/2021

    Impressed with the quality control. This product is a gem in our lab experiments.

    01/22/2019

      Smooth transactions and swift delivery. Our lab supplies are incomplete without this protein.

      04/17/2018

        Our lab manager introduced us to this product, and we're never going back. Essential for our studies.

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