||Truncated BID Mouse Recombinant also called BH3-interacting domain death agonist p15 produced inE.Coliis a single, non-glycosylated polypeptide chain containing 61-195 amino acids (135 a.a.) and having a molecular mass of 15.4 kDa.
||Truncated BH3 interacting domain death agonist is a truncated form of the pro-apoptotic full-length BID. Truncated BH3 interacting domain death agonist is generated by Caspase-8 cleavage of BID. The truncated form of the protein translocates from the cytosol to mitochondria and transduces apoptotic signals. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release.
||Sterile Filtered colorless liquid formulation.
||The Mouse Truncated BID protein solution contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl.
||Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
||TBID although stable at 15°C for 1 week, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.