"EPHA4" Related Products

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Recombinant Human EPH Receptor A4, GST-tagged, Active

Cat. No.: EPHA4-302H
Product Overview: Recombinant human EPHA4 (610-887) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=58kDa.
Description: EPHA4 also known as EPH receptor A4, belongs to the ephrin receptor subfamily of protein-tyrosine kinases which have been implicated in mediating developmental events, particularly in the nervous system. The EPHA4 ligand ephrin-A3 is localized to the astrocytic processes that envelop the spine. Activation of EPHA4 by ephrin-A3 induces spinal retraction and reduces spine density and inhibits the interaction distorted spine shape and organization. EPHA4-null mice possess defects in the corticospinal tract and anterior commissure indicating a model in which an ephrin ligand on the axons senses EPHA4 on spinal cord cells surrounding the corticospinal tract.
Source: Sf9 insect cellsusing baculovirus.
Sequence: 610-887.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: EPHA4 EPH receptor A4 [ Homo sapiens ]
Synonyms: EPHA4; EPH receptor A4; SEK; HEK8; TYRO1; OTTHUMP00000164185; TYRO1 protein tyrosine kinase; ephrin receptor EphA4; ephrin type-A receptor 4; receptor protein-tyrosine kinase HEK8; tyrosine-protein kinase receptor SEK; EC 2.7.10.1
Gene ID: 2043
mRNA Refseq: NM_004438
Protein Refseq: NP_004429
MIM: 602188
UniProt ID: P54764
Chromosome Location: 2q36.1
Pathway: Axon guidance
Function: ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity

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