Recombinant Human EPH Receptor A4, GST-tagged, Active EPHA4-302H

Recombinant Human EPH Receptor A4, GST-tagged, Active


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Recombinant Human EPH Receptor A4, GST-tagged, Active

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Cat. No. : EPHA4-302H
Product Overview : Recombinant human EPHA4 (610-887) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=58kDa.
Description : EPHA4 also known as EPH receptor A4, belongs to the ephrin receptor subfamily of protein-tyrosine kinases which have been implicated in mediating developmental events, particularly in the nervous system. The EPHA4 ligand ephrin-A3 is localized to the astrocytic processes that envelop the spine. Activation of EPHA4 by ephrin-A3 induces spinal retraction and reduces spine density and inhibits the interaction distorted spine shape and organization. EPHA4-null mice possess defects in the corticospinal tract and anterior commissure indicating a model in which an ephrin ligand on the axons senses EPHA4 on spinal cord cells surrounding the corticospinal tract.
Source : Sf9 insect cellsusing baculovirus.
Sequence : 610-887.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1b0x. :

Gene Name : EPHA4 EPH receptor A4 [ Homo sapiens ]
Synonyms : EPHA4; EPH receptor A4; SEK; HEK8; TYRO1; OTTHUMP00000164185; TYRO1 protein tyrosine kinase; ephrin receptor EphA4; ephrin type-A receptor 4; receptor protein-tyrosine kinase HEK8; tyrosine-protein kinase receptor SEK; EC
Gene ID : 2043
mRNA Refseq : NM_004438
Protein Refseq : NP_004429
MIM : 602188
UniProt ID : P54764
Chromosome Location : 2q36.1
Pathway : Axon guidance
Function : ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity

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