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Recombinant Human EPH Receptor A4, GST-tagged, Active

Cat.No. : EPHA4-302H
Product Overview : Recombinant human EPHA4 (610-887) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=58kDa.
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Cat. No. : EPHA4-302H
Description : EPHA4 also known as EPH receptor A4, belongs to the ephrin receptor subfamily of protein-tyrosine kinases which have been implicated in mediating developmental events, particularly in the nervous system. The EPHA4 ligand ephrin-A3 is localized to the astrocytic processes that envelop the spine. Activation of EPHA4 by ephrin-A3 induces spinal retraction and reduces spine density and inhibits the interaction distorted spine shape and organization. EPHA4-null mice possess defects in the corticospinal tract and anterior commissure indicating a model in which an ephrin ligand on the axons senses EPHA4 on spinal cord cells surrounding the corticospinal tract.
Source : Sf9 insect cellsusing baculovirus.
Sequence : 610-887.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : EPHA4 EPH receptor A4 [ Homo sapiens ]
Synonyms : EPHA4; EPH receptor A4; SEK; HEK8; TYRO1; OTTHUMP00000164185; TYRO1 protein tyrosine kinase; ephrin receptor EphA4; ephrin type-A receptor 4; receptor protein-tyrosine kinase HEK8; tyrosine-protein kinase receptor SEK; EC 2.7.10.1
Gene ID : 2043
mRNA Refseq : NM_004438
Protein Refseq : NP_004429
MIM : 602188
UniProt ID : P54764
Chromosome Location : 2q36.1
Pathway : Axon guidance
Function : ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does EPHA4 contribute to physiological processes and what is its specific role? 09/21/2021

EPHA4 is a member of the ephrin receptor family of protein kinases that plays an important role in neural development and synaptic plasticity. It is involved in axon guidance, neuronal migration, and cell proliferation.

What roles does the protein EPHA4 play in neuronal development? 01/19/2020

EPHA4 plays a critical role in neuronal development as a member of the Eph receptor family, which are receptor tyrosine kinases involved in various cellular processes. Specifically, EPHA4 regulates axon growth and guidance, acting as a repulsive cue to guide axons in the developing nervous system. Its involvement extends to synaptic plasticity and neuronal survival. Dysregulation of EPHA4 has been linked to neurological disorders, including Alzheimer's disease and neuropathic pain. Further research on the precise mechanisms and downstream signaling pathways of EPHA4 will deepen our understanding of its role in neuronal development and potential therapeutic applications.

How is EPHA4 expression regulated during development? 07/20/2019

EPHA4 expression is tightly regulated during nervous system development, with its expression gradually increasing during embryonic development. Additionally, EPHA4 expression is spatially regulated, with high levels in specific regions of the nervous system. Regulation of EPHA4 expression is mediated by several mechanisms, including transcriptional and post-transcriptional mechanisms.

How is EPHA4 involved in synaptic plasticity? 04/03/2018

EPHA4 is essential for normal synaptic plasticity, with its activation leading to the modulation of various synaptic proteins, such as AMPA receptors, NMDA receptors, and EphB receptors. Dysregulation of EPHA4-mediated signaling has been implicated in multiple neurodegenerative disorders, affecting both synaptic plasticity and axon growth.

What are the signaling mechanisms activated by EPHA4? 03/31/2018

EPHA4 signaling is initiated by binding to its ligands, which leads to activation of downstream signaling pathways. Several signaling pathways are activated by EPHA4, including the MAP kinase pathway, the PI3K-Akt pathway, and the RhoA-ROCK pathway, which play critical roles in the regulation of actin cytoskeleton dynamics.

Can EPHA4 be targeted therapeutically to treat neurodegenerative diseases? 04/07/2017

EPHA4 has emerged as a promising therapeutic target for various neurodegenerative diseases, and several pharmacological inhibitors have been developed to target EPHA4 signaling. These inhibitors have shown efficacy in preclinical models of several neurodegenerative diseases, suggesting their potential in clinical applications.

What is the role of genetic variants in the EPHA4 gene in neurodegenerative diseases? 09/29/2016

There is growing evidence that genetic variants in the EPHA4 gene may contribute to the susceptibility to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. These variants have been shown to modify EPHA4 expression and function, and may contribute to disease pathogenesis via several mechanisms, including synaptic dysfunction and axon degeneration.

Customer Reviews (3)

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Reviews
03/11/2020

    The results interpretation process with this protein reagent is straightforward, making it suitable for beginners as well.

    10/25/2019

      The composition ratio of the reagent is highly accurate, ensuring the reliability of the experimental results.

      06/10/2016

        Astounding in both reliability and steadfastness, it confers irrefutable persuasion to the experiment.

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