Recombinant Human GSK3A, GST-tagged, Active

• Cat.No.: GSK3A-325H
• Product Overview: Recombinant human Full-length GSK3alpha was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=81kDa.

Specification

• Cat. No.: GSK3A-325H
• Description: GSK3α is a multifunctional protein serine kinase, homologous to Drosophila "shaggy" (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and transcription factors (e.g., JUN). GSK3α also plays a role in the WNT and PI3K signaling pathways. Alzheimer disease is associated with increased production and aggregation of amyloid-beta-40 and -42 peptides into plaques. GSK3α is required for maximal production of the beta-amyloid-40 and -42 peptides generated from the amyloid precursor protein by presenilin-dependent gamma-secretase cleavage. In vitro, lithium, a GSK3α inhibitor, blocks the production of the beta-amyloid peptides by interfering with the gamma-secretase step.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: GSK3A glycogen synthase kinase 3 alpha [ Homo sapiens ]
• Synonyms: GSK3A; glycogen synthase kinase 3 alpha; DKFZp686D0638; Glycogen synthase kinase-3 alpha; GSK-3 alpha;EC2.7.11.26
• Gene ID: 2931
• mRNA Refseq: NM_019884
• Protein Refseq: NP_063937
• UniProt ID: P49840
• Chromosome Location: 19q13
• MIM: 606784
• Pathway: Chemokine signaling pathway; Signalling by NGF
• Function: ATP binding; protein binding; nucleotide binding; transferase activity; glycogen synthase kinase 3 activity; protein kinase A catalytic subunit binding; tau-protein kinase activity