Recombinant Human ERBB2, GST-tagged, Active

• Cat.No.: ERBB2-328H
• Product Overview: Recombinant human HER2 (676-end) was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=116kDa.

Specification

• Cat. No.: ERBB2-328H
• Description: HER2 gene encodes a cell-surface glycoprotein tyrosine kinase receptor with extensive homology to the epidermal growth factor receptor. HER2 is an oncogene and overexpression of unaltered HER2 coding sequences in NIH 3T3 cells results in cellular transformation and tumorigenesis. HER2 is amplified in about 30% of primary human breast malignancies and overexpression of HER2 is associated with the most aggressive tumors that show uncontrolled proliferation, resistance to apoptosis and increased motility.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 676-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [ Homo sapiens ]
• Synonyms: ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NEU; NGL; HER2; TKR1; CD340; HER-2; HER-2/neu; ERBB2; erbB-2; herstatin; c-erb B2/neu protein; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); C-erbB-2; EC 2.7.10.1; p185erbB2; CD340 antigen ; MLN 19; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2
• Gene ID: 2064
• mRNA Refseq: NM_001005862
• Protein Refseq: NP_001005862
• UniProt ID: P04626
• Chromosome Location: 17q11.2-q12
• MIM: 164870
• Pathway: Adherens junction; Bladder cancer; Calcium signaling pathway; Endometrial cancer; ErbB signaling pathway; Focal adhesion; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prostate cancer; Axon guidance
• Function: ATP binding; ErbB-3 class receptor binding; Hsp90 protein binding; epidermal growth factor receptor activity; glycoprotein binding; growth factor binding; identical protein binding; nucleotide binding; protein C-terminus binding; protein heterodimerization activity; protein phosphatase binding; receptor signaling protein tyrosine kinase activity; transferase activity; transmembrane receptor activity; ubiquitin protein ligase binding