"JAK3" Related Products

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Recombinant Human Janus Kinase 3, GST-tagged, Active

Cat. No.: JAK3-337H
Product Overview: Recombinant human JAK3 (781-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 64 kDa.
Description: JAK3 is a member of the JAK family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Low levels of JAK3 expression is detected in immature hematopoietic cells, which dramatically increases during terminal differentiation of these cells suggesting a role of JAK3 in the differentiation of hematopoietic cells. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease. Mice lacking JAK3 show a severe block in B-cell development at the pre-B stage in bone marrow suggesting that JAK3 is critical for the progression of B-cell development in the bone marrow.
Source: Sf9 insect cells using baculovirus.
Sequence: 781-end.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: JAK3 Janus kinase 3 [ Homo sapiens ]
Synonyms: JAK3; Janus kinase 3; JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; leukocyte Janus kinase; tyrosine-protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); EC 2.7.10.2
Gene ID: 3718
mRNA Refseq: NM_000215
Protein Refseq: NP_000206
MIM: 600173
UniProt ID: P52333
Chromosome Location: 19p13.1
Pathway: Chemokine signaling pathway; Jak-STAT signaling pathway; Primary immunodeficiency
Function: ATP binding; Janus kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity

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