||Recombinant human JAK3 (781-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 64 kDa.
||JAK3 is a member of the JAK family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Low levels of JAK3 expression is detected in immature hematopoietic cells, which dramatically increases during terminal differentiation of these cells suggesting a role of JAK3 in the differentiation of hematopoietic cells. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease. Mice lacking JAK3 show a severe block in B-cell development at the pre-B stage in bone marrow suggesting that JAK3 is critical for the progression of B-cell development in the bone marrow.
||Sf9 insect cells using baculovirus.
||Kinase Assay, Western Blot.
|Storage And Stability:
||Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.