"KDR" Related Products

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Recombinant Human Kinase Insert Domain Receptor, GST-tagged, Active

Cat. No.: KDR-340H
Product Overview: Recombinant human KDR (789-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 110 kDa.
Description: KDR (or kinase insert domain receptor) is a growth factor receptor tyrosine kinase that was originally isolated from human endothelial cells where it plays a pivotal role in endothelial cell proliferation and differentiation. KDR and its mouse homolog Flk1 bind VEGF with high affinity and are implicated in the development of new blood vessels (angiogenesis). The expression levels of VEGF and KDR are highly correlated during the normal development of the ocular vasculature in humans (1). Induction of angiogenesis is a critical step in tumor progression, and inhibitors of KDR have been demonstrated both to induce tumor regression and reduce metastatic potential in preclinical models.
Source: Sf9 insect cells using baculovirus.
Sequence: 789-end.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens ]
Synonyms: KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; EC 2.7.10.1; fetal liver kinase-1; soluble VEGFR2; tyrosine kinase growth factor receptor
Gene ID: 3791
mRNA Refseq: NM_002253
Protein Refseq: NP_002244
MIM: 191306
UniProt ID: P35968
Chromosome Location: 4q11-q12
Pathway: Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; VEGF signaling pathway; Signaling by VEGF
Function: ATP binding; growth factor binding; nucleotide binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

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