Active Recombinant Human Des(1-3)Insulin-like Growth Factor 1
Cat.No. : | IGF1-325H |
Product Overview : | Recombinant Human Des(1-3)Insulin-like Growth Factor1 (IGF1) was produced recombinantly. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IGF1-325H |
Description : | Human Des(1-3)Insulin-like Growth Factor 1 (IGF1) is a 67 amino acid analog of human IGF-I lacking the N-terminal tripeptide Gly-Pro-Glu. Human Des(1-3)IGF1 is more potent than IGF1 in vitro and in vivo. This increased potency is due to reduced binding of human Des(1-3)IGF1 to most of the IGF binding proteins which normally inhibit the biological actions of IGF1. Human Des(1-3)IGF1 binds to the Type 1 IGF receptor with similar affinity to full length IGF1. This is a high quality reagent for use in studies on cell growth, IGF receptors and IGFBPs. |
Source : | Produced recombinantly. |
Purity : | >95 % (by HPLC and N-terminal sequence analysis). |
Molecular Weight : | 7365 daltons – confirmed by Mass Spectrometry. |
N-terminal Sequence Analysis : | 5 residues > 95 % single sequence. |
Activity : | Type 1 IGF receptor binding assay: ED50< 10 ng/ml. IGF binding protein assay: ED50 > 100 ng/ml. Stimulation of protein synthesis in rat L6 myoblasts: ED50 < 10 ng/ml. |
Endotoxin : | <0.1 EU/µg. |
State And Appearance : | Lyophilized white powder. Dried from 0.1 M acetic acid and stored under dry nitrogen at a slight vacuum (-25 kPa). |
Storage : | At least 2 years at 2 – 4℃ (lyophilized). |
Gene Name : | IGF1 insulin-like growth factor 1 (somatomedin C) [ Homo sapiens ] |
Synonyms : | IBP1; IGF-I; IGF-IA; IGFI; MGF; Somatomedin-C; Mechano growth factor; insulin-like growth factor 1; insulin-like growth factor 1 (somatomedin C); somatomedin C; IGF1B_HUMAN; Insulin-like growth factor IB [Precursor]; IGF-IB. |
Gene ID : | 3479 |
mRNA Refseq : | NM_000618 |
Protein Refseq : | NP_000609 |
MIM : | 608747 |
UniProt ID : | P01343 |
Chromosome Location : | 12q23.2 |
Pathway : | Focal adhesion; Glioma; Long-term depression; Melanoma; Prostate cancer; mTOR signaling pathway; Hemostasis |
Function : | Growth factor activity; Hormone activity; Hormone activity; Insulin receptor binding; Insulin-like growth factor receptor binding; Protein binding |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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