Recombinant Human Des(1-3)Insulin-like Growth Factor 1 IGF1-325H

Recombinant Human Des(1-3)Insulin-like Growth Factor 1


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Recombinant Human Des(1-3)Insulin-like Growth Factor 1

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Cat. No. : IGF1-325H
Product Overview : Recombinant Human Des(1-3)Insulin-like Growth Factor1 (IGF1) was produced recombinantly.
Description : Human Des(1-3)Insulin-like Growth Factor 1 (IGF1) is a 67 amino acid analog of human IGF-I lacking the N-terminal tripeptide Gly-Pro-Glu. Human Des(1-3)IGF1 is more potent than IGF1 in vitro and in vivo. This increased potency is due to reduced binding of human Des(1-3)IGF1 to most of the IGF binding proteins which normally inhibit the biological actions of IGF1. Human Des(1-3)IGF1 binds to the Type 1 IGF receptor with similar affinity to full length IGF1. This is a high quality reagent for use in studies on cell growth, IGF receptors and IGFBPs.
Source : Produced recombinantly.
Purity : >95 % (by HPLC and N-terminal sequence analysis).
Molecular Weight : 7365 daltons – confirmed by Mass Spectrometry.
N-terminal Sequence Analysis : 5 residues > 95 % single sequence.
Activity : Type 1 IGF receptor binding assay: ED50< 10 ng/ml. IGF binding protein assay: ED50 > 100 ng/ml. Stimulation of protein synthesis in rat L6 myoblasts: ED50 < 10 ng/ml.
Endotoxin : <0.1 EU/µg.
State And Appearance : Lyophilized white powder. Dried from 0.1 M acetic acid and stored under dry nitrogen at a slight vacuum (-25 kPa).
Storage : At least 2 years at 2 – 4℃ (lyophilized).
Insulin-like growth factor 1 (somatomedin C), :

Gene Name : IGF1 insulin-like growth factor 1 (somatomedin C) [ Homo sapiens ]
Synonyms : IBP1; IGF-I; IGF-IA; IGFI; MGF; Somatomedin-C; Mechano growth factor; insulin-like growth factor 1; insulin-like growth factor 1 (somatomedin C); somatomedin C; IGF1B_HUMAN; Insulin-like growth factor IB [Precursor]; IGF-IB.
Gene ID : 3479
mRNA Refseq : NM_000618
Protein Refseq : NP_000609
MIM : 608747
UniProt ID : P01343
Chromosome Location : 12q23.2
Pathway : Focal adhesion; Glioma; Long-term depression; Melanoma; Prostate cancer; mTOR signaling pathway; Hemostasis
Function : Growth factor activity; Hormone activity; Hormone activity; Insulin receptor binding; Insulin-like growth factor receptor binding; Protein binding

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