IGF1

  • Official Full Name

    Insulin-like growth factor 1

  • Overview

    Insulin-like growth factor 1 (IGF-1) also known as somatomedin C is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.
  • Synonyms

    ProIGF-I; Insulin-like Growth Factor-I Precursor; IGF-IEB; IGF1; IGFI; Insulin-like Growth Factor-I; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; insulin-like growth factor I; Mechano growth factor; insulin-like growth factor IA; IGF-I; insulin-like growth factor IB; MGF; somatomedin-C; IGF-IA; IBP1; IGF-IB; Somatomedin-C; IGFI; Teprotumumab; 89957-37-9; Ganitumab; 905703-97-1;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Dog
  • Gilthead Seabream
  • Guinea pig
  • Human
  • Mouse
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Hordeum Vulgare
  • Human
  • Mammalian Cell
  • Mammalian cells
  • Oryza Sativa
  • Rice Grain
  • Synthetic Peptide
  • Yeast
  • Avi
  • Fc
  • C
  • His
  • Myc
  • DDK
  • His(C
  • ter)
  • GST
  • His (Fc)
  • His|GST
  • His|NusA
  • His|T7
  • HQ
  • human|IgG1|Fc
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IGF1-026E Active Recombinant Human IGF1 (26-95aa) E.coli N/A
Human IGF1-526H Active Recombinant Human IGF1 E.coli N/A
Human IGF1-325H Active Recombinant Human Des(1-3)Insulin-like Growth Factor 1 N/A
Human IGF1-650H Active Recombinant Human Insulin Like Growth Factor-I, HIgG1 Fc-tagged, mutant CHO Fc
Human IGF1-09H Active Recombinant Human IGF1 protein Rice Grain N/A
Human IGF1-652H Active Recombinant Human Insulin Like Growth Factor-I,HIgG1 Fc-tagged CHO Fc
Human IGF1-651H Active Recombinant Human Insulin Like Growth Factor-I, MIgG2a Fc-tagged CHO Fc
Human IGF1-658H Active Recombinant Human Insulin-like Growth Factor 1 Human N/A
Human IGF1-19HG Active Recombinant Human IGF1 Protein (Gly49-Ala118, Glu51Arg), GMP Grade, Animal-Free E.coli Gly49-Ala118, Glu51Arg
Human IGF1-810HG Active GMP Recombinant Human IGF1 protein E.coli N/A
Human IGF1-55H Active Recombinant Human IGF1 protein (Gly49-Ala118(Glu 51 Arg)) Yeast
Human IGF1-08H Active Recombinant HumanIGF1 Protein, HSA Conjugated Oryza Sativa N/A
Human IGF1-06H Recombinant Human IGF1 protein E.coli N/A 70
Human IGF1-61H Recombinant Human IGF1 Yeast N/A
Human IGF1-471H Recombinant Human IGF1 protein, His-tagged HEK293F His Gly49~Ala118
Human IGF1-691H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C), HQ-tagged Hordeum Vulgare HQ
Human IGF-08H Recombinant Human Long Arg3 Insulin-like Growth Factor-I E.coli N/A
Human IGF1-606H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C) Hordeum Vulgare N/A
Human IGF1-810H Recombinant Human IGF1 protein, His & GST-tagged E.coli His/GST Gly49~Ala118
Human IGF1-524H Recombinant Human IGF1 protein E.coli N/A 67
Human IGF1-687H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C) E.coli N/A
Human IGF1-036H Recombinant Human IGF1 Protein HEK293 N/A
Human IGF1-456H Recombinant Human Insulin-like Growth Factor 1 (Somatomedin C) Yeast N/A
Human IGF1-527H Recombinant Human IGF1 protein E.coli N/A 83
Human IGF1-657H Recombinant Human Insulin-Like Growth Factor 1, GST-tag Human GST
Human IGF1-561H Recombinant Human IGF1, His & NusA tagged E.coli His/NusA
Human IGF1-60H Active Recombinant Human IGF1 protein(Gly49-Ala118) E.coli N/A Gly49-Ala118
Human IGF1-5268HCL Recombinant Human IGF1 293 Cell Lysate HEK293 N/A
Human IGF1-384H Recombinant Human IGF1 protein, Fc-tagged HEK293 human/IgG1/Fc 70
Human IGF1-109H Recombinant Human Insulin-like growth Factor 1 Reference standard Yeast N/A
Human IGF1-175H Insulin-like growth Factor I Reference standard N/A
Human IGF1-P059H Recombinant Human IGF1 therapeutic protein E.coli N/A 70 Aa
Human IGF1-126H Recombinant Active Human IGF1 Protein, Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Gly49-Ala118
Human IGF1-867HG Active GMP Recombinant Human IGF1 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human IGF-1(NP_001104754.1) was expressed with Fc tag at the C-terminal.
Human IGF1-124HG GMP Recombinant Human IGF1 protein E.coli N/A 70
Human IGF1-3928H Recombinant Human IGF1 protein E.coli N/A 70
Human IGF1-127H Recombinant Active Human IGF1 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IGF1-057H Active Recombinant Human IGF1 Protein E.coli
Human IGF1-109I Active Recombinant Human IGF1 Protein (70 aa) E.coli 70
Human IGF1-020H Recombinant Human IGF1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human IGF1-23H Active Recombinant Human IGF1 Protein E.coli
Human IGF1-22H Recombinant Human/Bovine/Porcine IGF1 Protein E.coli
Human IGF1-053H Recombinant Human IGF1 Protein E.coli 195
Human IGF1-4120H Recombinant Human IGF1 protein, His-tagged E.coli His 49-118aa
Human IGF1-140H Recombinant Human IGF1 Protein E.coli
Human IGF1-119H Active Recombinant Human IGF1 Protein E.coli
Human IGF1-0243H Active Recombinant Human IGF1 protein, His-tagged HEK293 His Gly49-Ala118
Human IGF1-4121H Recombinant Human IGF1 protein, GST-tagged E.coli GST 49-118aa
Human IGF1-085I Active Recombinant Human LR3IGF1 Protein (83 aa) E.coli 83
Human IGF1-137H Active Recombinant Human IGF1 Protein E.coli Gly49-Ala118
Human IGF1-2505H Recombinant Human IGF1 Protein (Gly49-Ala118), C-His tagged E.coli C-His Gly49-Ala118
Human IGF1-21H Active Recombinant Human IGF1 Protein, Pre-aliquoted E.coli Gly49-Ala118
Human IGF1-086I Active Recombinant Human LR3IGF1 Protein (83 aa) E.coli 83
Human IGF1-376I Active Recombinant Human IGF1 Protein (70 aa) E.coli 70
Human IGF1-4256H Recombinant Human IGF1 Protein (Met1-Ala118), C-Fc tagged Mammalian cells C-Fc Met1-Ala118
Human IGF1-377I Active Recombinant Human IGF1 Protein (71 aa) E.coli 71
Human IGF1-339I Active Recombinant Human LR3IGF1 Protein (Receptor Grade) E.coli
Human IGF1-0242H Active Recombinant Human IGF1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gly49-Ala118
Human IGF1-868HG Active GMP Recombinant Human IGF1 protein HEK293 DNA sequence encoding Human IGF-1 LR 3(UniProtKB/Swiss-Prot: P05019) was expressed with His tag at the C-terminal.
Human IGF1-29HG Active Recombinant Human IGF1 Protein (Gly49-Ala118), GMP Grade, Animal-Free E.coli Gly49-Ala118
Human IGF1-2504H Recombinant Human IGF1 Protein (Gly49-Ala118), N-Fc tagged Mammalian cells N-Fc Gly49-Ala118
Human IGF1-558H Recombinant Human IGF1 Protein, Fc-tagged HEK293 Fc 195
Human IGF1-0245H Active Recombinant Human IGF1 protein, Avi-Fc-tagged, Biotinylated HEK293 Avi-Fc Gly49-Ala118
Human IGF1-0246H Active Recombinant Human IGF1 protein, Fc-tagged HEK293 Fc Gly49-Ala118
Human IGF1-2503H Recombinant Human IGF1 Protein (Met1-Ala118), C-Fc tagged Mammalian cells C-Fc Met1-Ala118
Human IGF1-158H Active Recombinant Human IGF1 Protein (Gly49-Ala118), C-His tagged, Animal-free, Carrier-free E.coli C-His Gly49-Ala118
Mouse Igf1-01M Active GMP Recombinant Mouse Igf1 Protein, His-Tagged E.coli His
Mouse Igf1-812M Recombinant Mouse Igf1 protein, His & T7-tagged E.coli His/T7 Gly49~Met153 (Accession # P05017)
Mouse Igf1-811M Recombinant Mouse Igf1 protein, His-tagged E.coli His Gly33~Ala102 (Accession # Q8CAR0)
Mouse Igf1-570M Recombinant Mouse Igf1 protein E.coli N/A 70
Mouse IGF1-8063M Recombinant Mouse IGF1 Protein Mammalian Cell His
Mouse Igf1-081M Recombinant Mouse Igf1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse IGF1-4460M-B Recombinant Mouse IGF1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Igf1-079M Active Recombinant Mouse Igf1 Protein E.coli
Mouse IGF1-437M Recombinant Mouse IGF1 protein(Gly49-Ala118) Yeast N/A Gly49-Ala118
Mouse Igf1-43M Active Recombinant Mouse Igf1 Protein (Gly49-Ala118), C-His tagged, Animal-free, Carrier-free E.coli C-His Gly49-Ala118
Mouse IGF1-0244M Active Recombinant Mouse IGF1 protein, Fc-tagged HEK293 Fc Gly49-Ala118
Mouse Igf1-375I Active Recombinant Mouse Igf1 Protein (71 aa) E.coli 71
Mouse Igf1-080M Active Recombinant Mouse Igf1 Protein E.coli
Mouse Igf1-128M Recombinant Active Mouse IGF1 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Igf1-1654M Recombinant Mouse Igf1 Protein, His-tagged E.coli N-His Gly49-Met153
Mouse Igf1-120M Active Recombinant Mouse IGF1 Protein E.coli
Mouse IGF1-4460M Recombinant Mouse IGF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Igf1-173R Active Recombinant Rat Igf1 E.coli N/A
Rat Igf1-814R Recombinant Rat Igf1 protein, His & GST-tagged E.coli His/GST Gly23~Ala92 (Accession # P08025)
Rat Igf1-604R Recombinant Rat Insulin-Like Growth Factor 1 E.coli N/A
Rat Igf1-590R Recombinant Rat Igf1 protein E.coli N/A 70
Rat Igf1-374I Active Recombinant Rat Igf1 Protein (71 aa) E.coli 71
Rat IGF1-121R Recombinant Rat IGF1 Protein E.coli
Rhesus monkey IGF1-2692R Recombinant Rhesus monkey IGF1 Protein, His-tagged E.coli N-His Gly49-Ala118
Rabbit IGF1-815R Recombinant Rabbit IGF1 protein, His & GST-tagged E.coli His/GST Gly33~Lys143 (Accession # Q95222<br />)
Dog IGF1-986D Recombinant Dog IGF1 Protein, His&GST-tagged E.coli N-His&GST Val22-Met153
Cattle IGF1-808C Recombinant Cattle IGF1 protein, His & GST-tagged E.coli His/GST Thr53~Lys132 (Accession # P07455)
Gilthead Seabream IGF1-84G Recombinant Gilthead Seabream Insulin-Like Growth Factor 1 E.coli N/A
Guinea pig Igf1-2817G Recombinant Guinea pig Igf1 Protein, His-tagged, OVA Conjugated Synthetic Peptide N-His
Porcine IGF1-01P GMP Recombinant Porcine IGF1 Protein, His-Tagged E.coli His
Rhesus Macaque IGF1-2215R Recombinant Rhesus monkey IGF1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IGF1-2036R Recombinant Rhesus Macaque IGF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IGF1-2036R-B Recombinant Rhesus Macaque IGF1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IGF1-9334Z Recombinant Zebrafish IGF1 Mammalian Cell His
Pig IGF1-813P Recombinant Pig IGF1 protein, GST-tagged E.coli GST Gly49~Ala118
Pig IGF1-210P Recombinant Pig IGF1 Protein (Gly49-Ala118), C-His tagged, Animal-free, Carrier-free E.coli C-His Gly49-Ala118
Chicken IGF1-322C Active Recombinant Chicken Insulin-Like Growth Factor 1 (Somatomedin C) E.coli N/A
Chicken IGF1-809C Recombinant Chicken IGF1 protein, His & GST-tagged E.coli His/GST Ser28~Met153 (Accession # P18254)
Chicken IGF1-1203C Recombinant Chicken IGF1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IGF1 involved in several pathways and played different roles in them. We selected most pathways IGF1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayPLCG1;RALGDS;FIGF;AKT2;RASSF1;GNG8;GNB4;Fgf15;RASAL2
Rap signaling pathwayPRKCI;RAF1;FGF18;PDGFB;RAP1GAP;TLN1;CALM3;PIK3R3;RASSF5
HIF- signaling pathwayAKT2;INS1;ENO2;Il6ra;MAPK3;HIF1A;PIK3R5;INS2;RBX1
FoxO signaling pathwayFOXG1;SOS1;PDPK1;PLK4;EP300;PIK3R3;SGK2;TGFBR1A;CCND2
Oocyte meiosisPPP2R5A;RPS6KA3A;MAD2L1;IGF1RA;CCNB1;CAMK2D2;PPP2R5C;CPEB1B;PPP1CAB
p signaling pathwaySESN1;Casp3;FAS;RRM2B;BIDA;CYCSB;RPRMA;EI24;SESN2
mTOR signaling pathwayEIF4BA;PIK3CG;HIF1A;RPS6KA3A;CAB39L;EIF4E2RS1;PTEN;MAPK3;PIK3CD
PIK-Akt signaling pathwayFGF9;LAMB3;RXRA;PCK1;YWHAG;GH2;TNXB;TSC1;FGF6
AMPK signaling pathwayFBP2;GYS2;ADRa1A;PRKAB1;MLYCD;PFKFB2;PCK2;PPP2R3A;EIF4EBP1
Focal adhesionTHBS2;COL5A2;BIRC3;COL4A2;RAF1A;PIK3CA;THBS3;MYL10;MYLPF
Signaling pathways regulating pluripotency of stem cellsINHBC;KLF4;BMP4;FGFR1;WNT9B;WNT8B;FGFR3;LEFTY2;HNF1A
Long-term depressionGNAO1;NOS1;GNAI2;GRIA3;PLCB4;NRAS;PRKG1;PPP2CB;GRIA2
Inflammatory mediator regulation of TRP channelsCYP2J2;PRKCE;TRPV2;IL1R1;CAMK2G;PRKCQ;IGF1;GNAS;GNAQ
Ovarian steroidogenesisACOT2;PLA2G4C;IGF1R;Adcy4;LHCGR;INS;PLA2G4F;AKR1C3;LDLR
Progesterone-mediated oocyte maturationCCNA2;CDH1-A;INS1;PRKACAB;ANAPC5;GNAIA;RPS6KA3B;CDC25B;INS2
Aldosterone-regulated sodium reabsorptionINS2;ATP1B3;PIK3R5;PIK3CA;ATP1B2;PIK3CG;HSD11B2;SFN;ATP1B4
Pathways in cancerMECOM;RXRG;GNAI2;PTGER3;PLCG2;RAF1;FH;LAMC2;STAT5B
Transcriptional misregulation in cancerETV1;ZBTB16;TRP53;HHEX;IGF1R;PROM1;MET;MAX;FLT1
Proteoglycans in cancerPIK3CA;FZD1;CTTN;CDC42;NRAS;CBLC;SLC9A1;FLNA;TWIST2
GliomaCALM3;KRAS;PIK3CB;SHC4;PIK3CD;IGF1R;PIK3R3;SOS1;RB1
Prostate cancerIGF1;ARAF;PTEN;FOXO1;SPRY1;MAPK3;PIK3CD;CCNE2;INS
MelanomaTP53;FGF20;PIK3R2;AKT2;FGF6;AKT1;PIK3CA;PIK3CD;CDH1
Hypertrophic cardiomyopathy (HCM)TPM1;CACNG4;CACNB3;DES;EMD;PRKAG2;MYH7;ITGB3;CACNB1
Dilated cardiomyopathyITGB5;GNAS;ACTB;LAMA2;MYL3;ITGA3;MYH7;ITGA2;TGFB3

IGF1 has several biochemical functions, for example, growth factor activity, hormone activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1 itself. We selected most functions IGF1 had, and list some proteins which have the same functions with IGF1. You can find most of the proteins on our site.

Function Related Protein
growth factor activityFGF6B;INHBA;FGF20B;AMH;F2;Artn;LEP;INHBE;HBEGF
hormone activityUCN3;GNRH2;GCGA;INHBC;INHBAB;CCL25;INSL3;GAST;FNDC5
insulin receptor bindingFRS2;IGF1;GRB10;INS;DOK4;PHIP;DOK3;DOK7;IRS1
insulin-like growth factor receptor bindingINSR;INSL4;SOCS2;SHC1;IRS1;IGF2;IGF1;PIK3R1;INS2
integrin bindingNpnt;THBS1;FBN1;SYK;ITGB1;ITGB1BP1;SFRP2;LAMA5;ITGB1BP2
protein bindingILK;FRMD7;NBR1;EPOR;SEC61B;RWDD2B;ATP6V1D;SNRNP25;DHX15

IGF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1.

IGF1R; Igfbp5; INSR

Research Area

Related articles

Luque, RM; Ibanez-Costa, A; et al. Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. CANCER LETTERS 359:299-306(2015).
Schofl, C; Grussendorf, M; et al. Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey. EUROPEAN JOURNAL OF ENDOCRINOLOGY 172:351-356(2015).
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Customer Reviews (3)

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Reviews
04/23/2022

    Range of applications of IGF1 is breathtaking, and it can play its unique advantage in any field.

    08/18/2021

      The biological activity and high purity of the protein are impressive, which is why it is a trusted partner in the field of scientific research.

      06/13/2021

        IGF1 can preserve its stability under extreme conditions, such as at high or low temperatures, which is very beneficial for our experiments.

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