igf1 Protein, Insulin-like growth factor 1

igf1

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igf1

Official Full Name Insulin-like growth factor 1
Background Insulin-like growth factor 1 (IGF-1) also known as somatomedin C is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.
Synonyms ProIGF-I; Insulin-like Growth Factor-I Precursor; IGF-IEB; IGF1; IGFI; Insulin-like Growth Factor-I; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; insulin-like growth factor I; Mechano growth factor; insulin-like growth factor IA; IGF-I; insulin-like growth factor IB; MGF; somatomedin-C; IGF-IA; IBP1; IGF-IB; Somatomedin-C; IGFI; Teprotumumab; 89957-37-9; Ganitumab; 905703-97-1
    • Species :
    • Cattle
    • Chicken
    • Gilthead Seabream
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Hordeum Vulgare
    • Human
    • Mammalian Cell
    • Rice Grain
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • NusA
    • T7
    • HQ
    • human
    • IgG1
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Igf1-079M Recombinant Mouse Igf1 Protein E.coli
    Mouse Igf1-080M Recombinant Mouse Igf1 Protein E.coli
    Mouse Igf1-081M Recombinant Mouse Igf1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human IGF1-384H Recombinant Human IGF1 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IGF1-3928H Recombinant Human IGF1 protein E.coli N/A
    Mouse IGF1-437M Recombinant Mouse IGF1 Protein Yeast N/A
    Human IGF-08H Recombinant Human Long Arg3 Insulin-like Growth Factor-I E.coli N/A
    Human IGF1-026E Recombinant Human IGF1 (26-95aa) E.coli N/A
    Human IGF1-036H Recombinant Human IGF1 Protein HEK293 N/A
    Human IGF1-06H Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-09H Recombinant Human IGF1 protein Rice Grain N/A
    Human IGF1-109H Recombinant Human Insulin-like growth Factor 1 Reference standard Yeast N/A
    Human IGF1-124HG GMP Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-175H Insulin-like growth Factor I Reference standard N/A
    Human IGF1-325H Recombinant Human Des(1-3)Insulin-like Growth Factor 1 N/A
    Human IGF1-456H Recombinant Human Insulin-like Growth Factor 1 (Somatomedin C) Yeast N/A
    Human IGF1-471H Recombinant Human IGF1 protein, His-tagged HEK293F His
    Human IGF1-524H Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-5268HCL Recombinant Human IGF1 293 Cell Lysate HEK293 N/A
    Human IGF1-526H Recombinant Human IGF1 E.coli N/A
    Human IGF1-527H Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-561H Recombinant Human IGF1, His & NusA tagged E.coli His/NusA
    Human IGF1-606H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C) Hordeum Vulgare N/A
    Human IGF1-60H Recombinant Human IGF1, None tagged E.coli N/A
    Human IGF1-61H Recombinant Human IGF1 Yeast N/A
    Human IGF1-650H Recombinant Human Insulin Like Growth Factor-I, HIgG1 Fc-tagged, mutant CHO Fc
    Human IGF1-651H Recombinant Human Insulin Like Growth Factor-I, MIgG2a Fc-tagged CHO Fc
    Human IGF1-652H Recombinant Human Insulin Like Growth Factor-I,HIgG1 Fc-tagged CHO Fc
    Human IGF1-657H Recombinant Human Insulin-Like Growth Factor 1, GST-tag Human GST
    Human IGF1-658H Recombinant Human Insulin-like Growth Factor 1 Human N/A
    Human IGF1-687H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C) E.coli N/A
    Human IGF1-691H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C), HQ-tagged Hordeum Vulgare HQ
    Human IGF1-810H Recombinant Human IGF1 protein, His & GST-tagged E.coli His/GST
    Human IGF1-P059H Recombinant Human IGF1 therapeutic protein E.coli N/A
    Mouse Igf1-570M Recombinant Mouse Igf1 protein E.coli N/A
    Mouse IGF1-8063M Recombinant Mouse IGF1 Protein Mammalian Cell His
    Mouse Igf1-811M Recombinant Mouse Igf1 protein, His-tagged E.coli His
    Mouse Igf1-812M Recombinant Mouse Igf1 protein, His & T7-tagged E.coli His/T7
    Rat Igf1-173R Recombinant Rat Igf1 E.coli N/A
    Rat Igf1-590R Recombinant Rat Igf1 protein E.coli N/A
    Rat Igf1-604R Recombinant Rat Insulin-Like Growth Factor 1 E.coli N/A
    Rat Igf1-814R Recombinant Rat Igf1 protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque IGF1-2215R Recombinant Rhesus monkey IGF1 Protein, His-tagged Mammalian Cell His
    Chicken IGF1-1203C Recombinant Chicken IGF1 Mammalian Cell His
    Chicken IGF1-322C Recombinant Chicken Insulin-Like Growth Factor 1 (Somatomedin C) E.coli N/A
    Chicken IGF1-809C Recombinant Chicken IGF1 protein, His & GST-tagged E.coli His/GST
    Rabbit IGF1-815R Recombinant Rabbit IGF1 protein, His & GST-tagged E.coli His/GST
    Zebrafish IGF1-9334Z Recombinant Zebrafish IGF1 Mammalian Cell His
    Cattle IGF1-808C Recombinant Cattle IGF1 protein, His & GST-tagged E.coli His/GST
    Pig IGF1-813P Recombinant Pig IGF1 protein, GST-tagged E.coli GST
    Gilthead Seabream IGF1-84G Recombinant Gilthead Seabream Insulin-Like Growth Factor 1 E.coli N/A

    igf1 involved in several pathways and played different roles in them. We selected most pathways igf1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with igf1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway RRAS2; MAPK9; FGF11; KIT; FGF19; FGF7; PRKCA; FGF6; PRKACB; PAK6
    Rap signaling pathway ITGB1; ARAP3; KRIT1; MAP2K3; PDGFRB; GNAQ; CDH1; NGF; PDGFA; PRKCB
    HIF- signaling pathway SERPINE1; IFNG; Il6ra; PIK3R5; PFKL; ENO1; INS; RELA; IGF1R; RPS6
    FoxO signaling pathway SGK1; TGFBR1A; STK11; CCND2; GADD45BA; FOXG1A; FOXO6; FASLG; RAF1A; ARAF
    Oocyte meiosis CALM3; SMC3; BUB1; ADCY1A; Adcy4; CCNB2; CAMK2G1; PKMYT1; PPP1CC; CPEB1
    p signaling pathway SESN1; CCNG1; RCHY1; SHISA5; GTSE1; GADD45AA; BAI1; BID; TNFRSF10B; FAS
    mTOR signaling pathway PIK3R5; HIF1A; POLDIP3; PRKAA1; PDPK1; PTENA; RPS6KA6; PRKCG; VEGFA; RRN3
    PIK-Akt signaling pathway GSK3B; PIK3R2; RELA; Il6ra; FGF12; STK11; G6PC2; Ifna15; F2R; Itga10&Itgb1
    AMPK signaling pathway PPP2CA; CCND1; PPP2R5C; MLYCD; CAB39; ULK1; INS2; CPT1B; Scd2; LEPR
    Focal adhesion RAC3B; IGF1; PTENB; COL5A2; Reln; LAMC2; TNXB; PARVG; COMP; VAV2
    Signaling pathways regulating pluripotency of stem cells ONECUT1; PIK3R5; FZD8; ID4; FGFR2; BMP2; WNT5B; Fzd4; WNT9A; STAT3
    Long-term depression PLCB1; RYR1; NOS1; PPP2CB; PPP2R1B; GUCY1A3; HRAS; GNAZ; GNA12; GNAI3
    Inflammatory mediator regulation of TRP channels PLA2G6; ASIC5; CYP2C39; HTR2A; ALOX12E; NGF; BDKRB2; CALM1; PPP1CC; PIK3CB
    Ovarian steroidogenesis HSD17B1; STAR; Adcy4; HSD3B1; LHB; PTGS2; IGF1R; CYP2J6; INSR; PRKACA
    Progesterone-mediated oocyte maturation IGF1RA; PRKACG; PPP1R2P9; CDC25B; HSP90AA1.2; KRAS; RPS6KA3; PKMYT1; INS; CDH1-A
    Aldosterone-regulated sodium reabsorption IGF1; ATP1A3; FXYD2; MAPK1; PIK3CG; KCNJ1; ATP1A1; PIK3R2; ATP1B4; ATP1B1
    Pathways in cancer ITGA6; RB1; GNGT2; CBLC; LAMB2; Flt3l; CASP9; FADD; SLC2A1; STAT5A
    Transcriptional misregulation in cancer PBX3; TRP53; NFKBIZ; WNT16; REL; PRCC; LMO2; SSX2; MET; HHEX
    Proteoglycans in cancer TIMP3; WNT16; ARHGEF12; HCLS1; PPP1R12C; TP53; PTK2; FGFR1; FAS; PLCG2
    Glioma CCND1; TP53; AKT1; PIK3R5; SHC2; MAP2K1; MDM2; IGF1; PDGFRA; RB1
    Prostate cancer INS1; CCND1; KRAS; ERBB2; ATF4; Pdgfa&Pdgfb; INSRR; INS; FOXA1; RAF1
    Melanoma FGF4; TRP53; FGF3; PIK3R5; PDGFRA; MITF; FGF18; MAPK1; FGF6; FGF14
    Hypertrophic cardiomyopathy (HCM) PRKAG3; ITGA2; CACNG3; TPM3; PRKAG2; CACNA2D4; ITGA7; ITGB5; DES; CACNA2D3
    Dilated cardiomyopathy DAG1; CACNG6; CACNG2; ATP2A2; ITGB5; TGFB1; ITGB1; CACNA2D4; ITGA6; ITGA5

    igf1 has several biochemical functions, for example, growth factor activity, hormone activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by igf1 itself. We selected most functions igf1 had, and list some proteins which have the same functions with igf1. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity FGF21; MIA; FGF22; MDK; BMP6; OSM; FGF6B; KLK1B4; EREG; BMP16
    hormone activity GAST; RETNLB; SST6; URP2; SCT; GIP; AMH; TSHB; LEPA; CALCA
    insulin receptor binding FRS2A; PDPK1; INS; SNX1; PTPN11; SNX4; FRS3; LMBRD1; INS1; IGF1
    insulin-like growth factor receptor binding PIK3R1; SHC1; INSL4; IGF1; GNAS; INSR; YWHAG; INS2; ARRB1; Ren1
    integrin binding ITGB1; ITGB1BP2; CYR61L1; SFRP2; COL5A1; JAM3; ACTN4; ESM1; VWF; ILK
    protein binding MAP2K3; SLC22A7; CHCHD3; P2RX7; RFX6; RCAN1; NKD1; OCIAD1; GSE1; TMSB4Y

    igf1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with igf1 here. Most of them are supplied by our site. Hope this information will be useful for your research of igf1.

    IGF1R; Igfbp5; INSR

    Luque, RM; Ibanez-Costa, A; et al. Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. CANCER LETTERS 359:299-306(2015).
    Schofl, C; Grussendorf, M; et al. Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey. EUROPEAN JOURNAL OF ENDOCRINOLOGY 172:351-356(2015).

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