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Official Full Name Insulin-like growth factor 1
Background Insulin-like growth factor 1 (IGF-1) also known as somatomedin C is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.
Synonyms ProIGF-I; Insulin-like Growth Factor-I Precursor; IGF-IEB; IGF1; IGFI; Insulin-like Growth Factor-I; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; insulin-like growth factor I; Mechano growth factor; insulin-like growth factor IA; IGF-I; insulin-like growth factor IB; MGF; somatomedin-C; IGF-IA; IBP1; IGF-IB; Somatomedin-C; IGFI; Teprotumumab; 89957-37-9; Ganitumab; 905703-97-1
    • Species :
    • Cattle
    • Chicken
    • Gilthead Seabream
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Hordeum Vulgare
    • Human
    • Mammalian Cell
    • Rice Grain
    • Yeast
    • Tag :
    • C-Myc/DDK
    • Fc
    • GST
    • His
    • NusA
    • T7
    • HQ
    • human
    • IgG1
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IGF1-057H Recombinant Human IGF1 Protein E. coli
    Human IGF-08H Recombinant Human Long Arg3 Insulin-like Growth Factor-I E.coli N/A
    Human IGF1-020H Recombinant Human IGF1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human IGF1-026E Recombinant Human IGF1 (26-95aa) E.coli N/A
    Human IGF1-036H Recombinant Human IGF1 Protein HEK293 N/A
    Human IGF1-06H Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-09H Recombinant Human IGF1 protein Rice Grain N/A
    Human IGF1-109H Recombinant Human Insulin-like growth Factor 1 Reference standard Yeast N/A
    Human IGF1-124HG GMP Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-175H Insulin-like growth Factor I Reference standard N/A
    Human IGF1-325H Recombinant Human Des(1-3)Insulin-like Growth Factor 1 N/A
    Human IGF1-384H Recombinant Human IGF1 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IGF1-3928H Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-456H Recombinant Human Insulin-like Growth Factor 1 (Somatomedin C) Yeast N/A
    Human IGF1-471H Recombinant Human IGF1 protein, His-tagged HEK293F His
    Human IGF1-524H Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-5268HCL Recombinant Human IGF1 293 Cell Lysate HEK293 N/A
    Human IGF1-526H Recombinant Human IGF1 E.coli N/A
    Human IGF1-527H Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-55H Recombinant Human IGF1 protein (Gly49-Ala118(Glu 51 Arg)) Yeast
    Human IGF1-561H Recombinant Human IGF1, His & NusA tagged E.coli His/NusA
    Human IGF1-606H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C) Hordeum Vulgare N/A
    Human IGF1-60H Recombinant Human IGF1, None tagged E.coli N/A
    Human IGF1-61H Recombinant Human IGF1 Yeast N/A
    Human IGF1-650H Recombinant Human Insulin Like Growth Factor-I, HIgG1 Fc-tagged, mutant CHO Fc
    Human IGF1-651H Recombinant Human Insulin Like Growth Factor-I, MIgG2a Fc-tagged CHO Fc
    Human IGF1-652H Recombinant Human Insulin Like Growth Factor-I,HIgG1 Fc-tagged CHO Fc
    Human IGF1-657H Recombinant Human Insulin-Like Growth Factor 1, GST-tag Human GST
    Human IGF1-658H Recombinant Human Insulin-like Growth Factor 1 Human N/A
    Human IGF1-687H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C) E.coli N/A
    Human IGF1-691H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C), HQ-tagged Hordeum Vulgare HQ
    Human IGF1-810H Recombinant Human IGF1 protein, His & GST-tagged E.coli His/GST
    Human IGF1-867HG GMP Recombinant Human IGF1 protein, Fc-tagged HEK293 Fc
    Human IGF1-868HG GMP Recombinant Human IGF1 protein, His-tagged HEK293 His
    Human IGF1-P059H Recombinant Human IGF1 therapeutic protein E.coli N/A
    Mouse Igf1-079M Recombinant Mouse Igf1 Protein E.coli
    Mouse Igf1-080M Recombinant Mouse Igf1 Protein E.coli
    Mouse Igf1-081M Recombinant Mouse Igf1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse IGF1-437M Recombinant Mouse IGF1 Protein Yeast N/A
    Mouse Igf1-570M Recombinant Mouse Igf1 protein E.coli N/A
    Mouse IGF1-8063M Recombinant Mouse IGF1 Protein Mammalian Cell His
    Mouse Igf1-811M Recombinant Mouse Igf1 protein, His-tagged E.coli His
    Mouse Igf1-812M Recombinant Mouse Igf1 protein, His & T7-tagged E.coli His/T7
    Rat Igf1-173R Recombinant Rat Igf1 E.coli N/A
    Rat Igf1-590R Recombinant Rat Igf1 protein E.coli N/A
    Rat Igf1-604R Recombinant Rat Insulin-Like Growth Factor 1 E.coli N/A
    Rat Igf1-814R Recombinant Rat Igf1 protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque IGF1-2215R Recombinant Rhesus monkey IGF1 Protein, His-tagged Mammalian Cell His
    Chicken IGF1-1203C Recombinant Chicken IGF1 Mammalian Cell His
    Chicken IGF1-322C Recombinant Chicken Insulin-Like Growth Factor 1 (Somatomedin C) E.coli N/A
    Chicken IGF1-809C Recombinant Chicken IGF1 protein, His & GST-tagged E.coli His/GST
    Rabbit IGF1-815R Recombinant Rabbit IGF1 protein, His & GST-tagged E.coli His/GST
    Zebrafish IGF1-9334Z Recombinant Zebrafish IGF1 Mammalian Cell His
    Cattle IGF1-808C Recombinant Cattle IGF1 protein, His & GST-tagged E.coli His/GST
    Pig IGF1-813P Recombinant Pig IGF1 protein, GST-tagged E.coli GST
    Gilthead Seabream IGF1-84G Recombinant Gilthead Seabream Insulin-Like Growth Factor 1 E.coli N/A

    igf1 involved in several pathways and played different roles in them. We selected most pathways igf1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with igf1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway PLA2G4A; MRAS; RASGRP3; GNG8; FASLG; FLT1; PLA2G1B; PIK3CD; CALM3; FGF22
    Rap signaling pathway IGF1; Pdgfa&Pdgfb; Kitl; FARP2; FGF17; RALGDS; GNAQ; FGF6; MLLT4; FGF7
    HIF- signaling pathway ENO2; PRKCB; HIF1A; INS2; IFNGR2; PDHB; STAT3; ALDOA; PFKL; AKT2
    FoxO signaling pathway STK11; MAPK8; PCK2; BCL6A; RAG1; PTENB; TGFB3; USP7; PLK4; MAPK1
    Oocyte meiosis YWHAG; PPP1CB; CALM2B; PPP3CA; Adcy4; PLCZ1; CALM2A; CALM; CCNE2; SLKA
    p signaling pathway BID; TP53I3; SFN; MDM4; SESN2; RFWD2; PTEN; CCNG2; SIAH1A; ZMAT3
    mTOR signaling pathway RPS6; POLDIP3; RHEB; TSC1; RPS6KB1B; HIF1A; EIF4BA; PDPK1B; EIF4E2; PIK3R2
    PIK-Akt signaling pathway YWHAE; IGF1; EPO; IFNAR1; FGF22; GNG2; LAMA5; PPP2R5B; LAMB2; PPP2R3C
    AMPK signaling pathway PPP2CA; CAMKK1; EIF4EBP1; ADIPOR1; PPP2R5D; GYS2; PCK1; PPP2R5C; PIK3CG; RAB10
    Focal adhesion SHC1; RHOAC; MYL9B; CAV3; COL2A1A; ITGB1; THBS4B; PIP5K1C; RHOAD; FN1
    Signaling pathways regulating pluripotency of stem cells IGF1; FZD5; SMAD5; ID4; ZIC3; HNF1A; LHX5; WNT7B; Fzd4; INHBE
    Long-term depression MAPK3; GNA13; PRKCB; ITPR3; MAP2K1; PLCB1; PPP2CA; GRIA1; PPP1R17; GRIA2
    Inflammatory mediator regulation of TRP channels PIK3R5; TRPV4; HRH1; CAMK2G; PRKCD; PRKCA; MAPK9; PLA2G4D; TRPM8; MAP2K6
    Ovarian steroidogenesis INSR; INS; AKR1C3; HSD17B7; BMP6; PLA2G4C; FSHB; PRKACB; PLA2G4A; ACOT2
    Progesterone-mediated oocyte maturation GNAI2; BUB1; MAPK1; MAD2L2; CCNB3; PRKACA; PIK3R3B; MAPK12B; ANAPC11; MAPK11
    Aldosterone-regulated sodium reabsorption INS1; ATP1B3; FXYD4; HSD11B2; ATP1B1; SCNN1B; PDPK1; PIK3R2; INS; INSR
    Pathways in cancer GNG13; MAPK10; GNAS; WNT4; NRAS; PTGER2; ABL1; EPAS1; CTNNA3; BCL2L1
    Transcriptional misregulation in cancer ETV4; CDK14; MPO; ELANE; DOT1L; MEN1; NR4A3; TRAF1; LMO2; IL1R2
    Proteoglycans in cancer PPP1R12C; TWIST1; WNT3; FAS; Fzd4; KRAS; MSN; HIF1A; WNT7A; PTK2
    Prostate cancer PDGFD; FOXO1; BRAF; NOXA1; CCNE2; NKX3-1; MAP4K1; MAPK3; HSP90AB1; BCL2
    Melanoma IGF1R; PDGFD; FGFR1; FGF19; MET; BRAF; FGF9; MDM2; KRAS; FGF21
    Hypertrophic cardiomyopathy (HCM) TNNI3; CACNA2D2; CACNA2D4; ITGB1; CACNB1; ATP2A2; ITGB4; ACE; DES; SGCG
    Dilated cardiomyopathy ITGB5; TTN; ITGB6; SGCG; SGCB; LMNA; CACNG6; TGFB3; ATP2A2; LAMA2

    igf1 has several biochemical functions, for example, growth factor activity, hormone activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by igf1 itself. We selected most functions igf1 had, and list some proteins which have the same functions with igf1. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity HGF; PPBP; BMP8B; EPGN; FGF8B; BMP3; DKK1; NGF; INHBA; BMP6
    hormone activity UCN2; C1QTNF9; LRSAM1; INS-IGF2; AMH; GNRH2; PYYA; POMCA; GALP; PRL7A1
    insulin receptor binding LMBRD1; IRS1; PTPN1; INS1; FRS2B; DOK7; INSL3; DOK2; FRS2; DOK4
    insulin-like growth factor receptor binding IRS1; REN; GNAS; ARRB1; IGF2A; YWHAH; IGF3; IGF2; INS; INS2
    integrin binding FERMT3; CYR61L1; WISP1A; THY1; ANGPTL3; ICAM3; ACTN1; ILK; S1PR3; CTGF
    protein binding SLC6A4; MARCKSL1; RAB11FIP5; RPIA; KIAA0141; NEFL; CPS1; SMARCE1; FOXRED2; TCF25

    igf1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with igf1 here. Most of them are supplied by our site. Hope this information will be useful for your research of igf1.

    IGF1R; Igfbp5; INSR

    Luque, RM; Ibanez-Costa, A; et al. Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. CANCER LETTERS 359:299-306(2015).
    Schofl, C; Grussendorf, M; et al. Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey. EUROPEAN JOURNAL OF ENDOCRINOLOGY 172:351-356(2015).

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