IGF1
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Official Full Name
Insulin-like growth factor 1
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Overview
Insulin-like growth factor 1 (IGF-1) also known as somatomedin C is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons. -
Synonyms
ProIGF-I; Insulin-like Growth Factor-I Precursor; IGF-IEB; IGF1; IGFI; Insulin-like Growth Factor-I; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; insulin-like growth factor I; Mechano growth factor; insulin-like growth factor IA; IGF-I; insulin-like growth factor IB; MGF; somatomedin-C; IGF-IA; IBP1; IGF-IB; Somatomedin-C; IGFI; Teprotumumab; 89957-37-9; Ganitumab; 905703-97-1;
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- Involved Pathway
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IGF1 involved in several pathways and played different roles in them. We selected most pathways IGF1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | CALM3;IKBKG;RELA;GRB2;NRAS;RAB5B;RIN1;PLD1;ELK1 |
| Rap signaling pathway | RASSF5;PARD3;RALGDS;SKAP1;SIPA1L1;Adcy4;RALB;PDGFD;PFN2 |
| HIF- signaling pathway | RPS6KB1;FLT1;RPS6;STAT3;HMOX1;PDHA1;PDHA2;PFKFB3;NOX1 |
| FoxO signaling pathway | PRKAG1;HRASB;BNIP3;GABARAPL1;SGK2B;PRMT1;TGFB3;MAPK1;HOMER3 |
| Oocyte meiosis | INS2;SMC1B;CDK1;CDC16;IGF1;SKP1;CPEB4;CAMK2G;CAMK2D1 |
| p signaling pathway | RPRM;CYCS;CCNG2;CCNB2;PMAIP1;TSC2;COP1;CCNB3;CCNE1 |
| mTOR signaling pathway | HIF1A;STRADA;ULK1;MAPK3;PIK3R1;PRKCG;POLDIP3;PTENA;ULK3 |
| PIK-Akt signaling pathway | PDGFRB;VTN;FLT4;IL2RB;IRS1;THBS2;LAMA3;IFNA13;AKT2 |
| AMPK signaling pathway | PPP2R1B;PPP2CB;FOXO1;FOXO3;RAB11B;CPT1A;CREB3L1;RPTOR;PPP2R5C |
| Focal adhesion | RAC1B;LAMA1;RHOAB;PRKCA;RAF1B;LAMC3;PAK6B;MYL9A;PDGFD |
| Signaling pathways regulating pluripotency of stem cells | WNT11;FGFR4;FGFR1;SMARCAD1;HOXB1;PIK3R3;WNT9B;WNT9A;SMAD5 |
| Long-term depression | MAPK3;PPP2R1B;PPP2CB;PRKG2;GNAS;IGF1;GNAZ;MAP2K1;GUCY1A3 |
| Inflammatory mediator regulation of TRP channels | PRKCD;PRKCQ;PIK3R5;CALML3;CAMK2A;CYP4A10;PLA2G4A;PIK3R1;ACCN3 |
| Ovarian steroidogenesis | HSD3B6;INS;INS1;HSD3B2;SCARB1;FSHB;HSD17B1;PLA2G4A;PTGS2 |
| Progesterone-mediated oocyte maturation | BRAF;PLK1;PPP1R2P9;KRAS;MAPK10;AKT3A;GNAI2A;CPEB3;PRKACBB |
| Aldosterone-regulated sodium reabsorption | KRAS;INS2;INS;PIK3R2;ATP1A4;SCNN1G;PIK3CB;INS1;FXYD4 |
| Pathways in cancer | BCL2L1;Fzd4;LAMA4;MSH2;Fgf15;TRAF6;FGF5;LAMA1;Casp3 |
| Transcriptional misregulation in cancer | RELA;TAF15;LRP2BP;BIRC3;H3F3B;SP1;HIST1H3E;TLX1;EWSR1 |
| Proteoglycans in cancer | WNT9B;PPP1CA;MAPK1;ITGB5;WNT5A;RPS6KB2;PTPN11;GRB2;TGFB1 |
| Glioma | CAMK2A;KRAS;SOS1;IGF1R;CAMK2G;BRAF;CALM4;CALM2;SHC3 |
| Prostate cancer | INS2;NDRG1;GSTP1;IGF1R;HSP90B1;PDPK1;MAP2K2;MAP4K1;BRAF |
| Melanoma | Fgf15;MDM2;MAPK1;Pdgfa&Pdgfb;MAP2K2;FGF12;NRAS;CDH1;FGF8 |
| Hypertrophic cardiomyopathy (HCM) | CACNB1;ACTG1;ATP2A2;TPM3;MYBPC3;IGF1;CACNA2D4;CACNB3;ITGB7 |
| Dilated cardiomyopathy | PRKACB;DES;ITGB1;IGF1;TGFB3;ACTG1;CACNG1;CACNA2D4;ITGA8 |
IGF1 has several biochemical functions, for example, growth factor activity, hormone activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1 itself. We selected most functions IGF1 had, and list some proteins which have the same functions with IGF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | BMP10;GDF10;IL5;CTGF;CSF1B;CNTF;NODAL;HDGFRP3;IL9 |
| hormone activity | C19orf80;PRL8A9;AMH;SST1.1;UCN3;VIP;GH1;CSH1;CRH |
| insulin receptor binding | DOK7;PHIP;DOK3;IRS2;INS1;IGF2;DOK4;IGF1;IGF1R |
| insulin-like growth factor receptor binding | GNAS;INSL4;YWHAG;IGF2A;INS;Ren1;INSR;YWHAH;PIK3R1 |
| integrin binding | NISCH;P4HB;IGF1;ACTN1;SYK;ADAMTS5;FAP;ITGA3;LYN |
| protein binding | NFKB2;ZNF350;FNIP1;PALLD;JAKMIP1;STXBP4;MAFG;PSMA1;MAMSTR |
IGF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1.
IGF1R; Igfbp5; INSR
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Customer Reviews (3)
Write a reviewRange of applications of IGF1 is breathtaking, and it can play its unique advantage in any field.
The biological activity and high purity of the protein are impressive, which is why it is a trusted partner in the field of scientific research.
IGF1 can preserve its stability under extreme conditions, such as at high or low temperatures, which is very beneficial for our experiments.
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