IGF1
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Official Full Name
Insulin-like growth factor 1 -
Overview
Insulin-like growth factor 1 (IGF-1) also known as somatomedin C is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons. -
Synonyms
ProIGF-I;Insulin-like Growth Factor-I Precursor;IGF-IEB;IGF1;IGFI;Insulin-like Growth Factor-I;insulin-like growth factor 1 (somatomedin C);insulin-like growth factor 1;IGF1A;insulin-like growth factor I;Mechano growth factor;insulin-like growth factor IA;IGF-I;insulin-like growth factor IB;MGF;somatomedin-C;IGF-IA;IBP1;IGF-IB;Somatomedin-C;IGFI;Teprotumumab;89957-37-9;Ganitumab;905703-97-1
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Bovine
- Rhesus macaque
- Cattle
- Pig
- Rabbit
- Gilthead Seabream
- Zebrafish
- Porcine
- Guinea pig
- Dog
- E.coli
- Rice Grain
- CHO
- Human
- Oryza Sativa
- Yeast
- HEK293
- Mammalian Cells
- Hordeum Vulgare
- Synthetic
- Non
- Fc
- His
- NusA
- GST
- HQ
- T7
- DDK
- Myc
- Avi
Involved Pathway
IGF1 involved in several pathways and played different roles in them. We selected most pathways IGF1 participated on our site, such as Ras signaling pathway,Rap signaling pathway,HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Long-term depression | GRM1,GNAI3,PPP2R1A,GNA13,NOS1,GNAO1,ARAF,MAPK3,PPP1R17,RAF1 |
| Ovarian steroidogenesis | HSD3B4,PLA2G4A,HSD17B1,STAR,CYP2J5,INS,FSHB,HSD17B2,PLA2G4D,LHB |
| mTOR signaling pathway | MAPK1,PRKAA2,AKT1,RPS6KA3B,ULK3,PRKCA,MTOR,STK11,BRAF,ULK1 |
| FoxO signaling pathway | CAT,PTEN,TGFB2,CCND1,GADD45AA,AKT2,INS,MAPK11,FOXO3A,FASLG |
| Pathways in cancer | ITGA6,PRKCB,KRAS,NRAS,RELA,STK4,Fasl,WNT16,WNT2,TCEB1 |
| Focal adhesion | FYNA,ITGA9,STYK1,CAV3,COL2A1,TLN1,PIK3CB,CDC42L,HRAS,HRASA |
| Transcriptional misregulation in cancer | JMJD1C,HDAC1,NGFR,HIST1H3F,MEIS1,BCL2A1,MET,GOLPH3,ASPSCR1,MLLT3 |
| Glioma | PLCG1,PRKCA,CALM2,AKT1,HRAS,PRKCG,IGF1R,KRAS,AKT2,SHC1 |
| Oocyte meiosis | PRKACG,SMC1B,SGOL1,CAMK2G1,CDC27,SKP1,AURKA,RPS6KA2,PPP3CA,CAMK2G |
Protein Function
IGF1 has several biochemical functions, for example, growth factor activity,hormone activity,insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1 itself. We selected most functions IGF1 had, and list some proteins which have the same functions with IGF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hormone activity | CCL25,UTS2,GNRH3,TG,LRSAM1,CRH,PRL3C1,PRL2C3,NMB,IAPP |
| insulin-like growth factor receptor binding | SOCS1,Ren1,IGF3,INS2,INSL4,YWHAH,REN,IGF2A,SOCS2,YWHAG |
| integrin binding | ADAM22,ADAM15,VTN,S1PR2,ADAMTS8,ITGA5,ADAM10,ADAM23,TNN,ICAM1 |
| protein binding | CREB3L1,GHR,LCAT,HIST1H2BI,FOXR1,SNRNP40,MOXD1,TNFRSF14,LYRM2,TNFRSF21 |
| growth factor activity | TDGF1,FGF21,FGF18B,FGF20,PROK1,FGF3,PDGFC,HDGFRP3,BMP7A,FGF17 |
| insulin receptor binding | SNX2,SHC1,IGF2,DOK2,GRB10,INS,LMBRD1,FRS3,IRS2,SNX1 |
Interacting Protein
IGF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1.
IGF1R;Igfbp5;INSR
Resources
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Understanding IGF-1 Protein: Structure, Function, and Applications
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IGF-1 Protein: Structure, Function, and Applications in 60 Seconds!
Gene Families
Research Area
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References
- Luque, RM; Ibanez-Costa, A; et al. Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. CANCER LETTERS 359:299-306(2015).
- Schofl, C; Grussendorf, M; et al. Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey. EUROPEAN JOURNAL OF ENDOCRINOLOGY 172:351-356(2015).
