Recombinant Human DAPK3, 1-659, GST-tagged, Active DAPK3-292H

Recombinant Human DAPK3, 1-659, GST-tagged, Active

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Recombinant Human DAPK3, 1-659, GST-tagged, Active

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Cat. No. : DAPK3-292H
Product Overview : Recombinant humanDAPK3 (1-659) was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW=101kDa.
Description : DAPK3 or Death-associated protein kinase 3 (also known as ZIP) plays a role in apoptosis. DAPK3 is a nuclear serine/threonine-specific kinase that phosphorylates core histones H3 and H4, and myosine light chain in vitro. DAPK3 interacts with transcription and splicing factors as well as with pro-apoptotic protein Par-4 suggesting that it participates in multiple cellular processes. DAPK3 contains a leucine zipper structure at its C terminus and this region is responsible for binding to ATF4. The leucine zipper domain is necessary for the homodimerization of DAPK3 as well as for the activation of the kinase.
Source : Sf9 insect cellsusing baculovirus.
Sequence : 1-659.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1yrp. :

Gene Name : DAPK3 death-associated protein kinase 3 [ Homo sapiens ]
Synonyms : DAPK3; death-associated protein kinase 3; ZIP; ZIPK; FLJ36473; ZIP kinase isoform; EC 2.7.11.1; ZIP-kinase
Gene ID : 1613
mRNA Refseq : NM_001348
Protein Refseq : NP_001339
MIM : 603289
UniProt ID : O43293
Chromosome Location : 19p13.3
Pathway : Bladder cancer; Pathways in cancer
Function : ATP binding; calmodulin binding; nucleotide binding ; protein serine/threonine kinase activity transferase activity

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