Recombinant Human DAPK2, GST-tagged, Active
Cat.No. : |
DAPK2-290H |
Product Overview : |
Recombinant human full-length DAPK2 was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW= 67kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : |
DAPK2-290H |
Description : |
DAPK2 or death-associated protein kinase 2 belongs to a family of proapoptotic Ca /calmodulin-regulated serine/threonine kinases. Overexpression of DAPK2 induces cell apoptosis. DAPK2 has been shown to be a novel Sp1-dependent target gene for E2F1 and Krüppel-like factor 6 (KLF6) in cell death response. Both E2F1 and KLF6 strongly activate the DAPK2 promoter. DAPK2 plays a role in granulopoiesis where it is highly expressed. β-catenin can block anoikis of malignant kidney and intestinal epithelial cells and promote their anchorage-independent growth by down-regulating DAPK2. β-catenin-induced down-regulation of DAPK2 requires the presence of the transcription factor TCF-4. |
Source : |
Sf9 insect cellsusing baculovirus. |
Sequence : |
Full-length. |
Applications : |
Kinase Assay, Western Blot. |
Storage And Stability : |
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : |
DAPK2 death-associated protein kinase 2 [ Homo sapiens ] |
Synonyms : |
DAPK2; death-associated protein kinase 2; DRP1; DRP-1; MGC119312; DAP kinase 2; OTTHUMP00000163874; DAP-kinase-related protein 1; EC 2.7.11.1 |
Gene ID : |
23604 |
mRNA Refseq : |
NM_014326 |
Protein Refseq : |
NP_055141 |
UniProt ID : |
Q9UIK4 |
Chromosome Location : |
15q22.31 |
Pathway : |
Bladder cancer; Pathways in cancer |
Function : |
ATP binding; calmodulin binding; nucleotide binding ; protein serine/threonine kinase activity transferase activity |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.