Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human BRAF, GST-tagged, Active

Cat.No. : BRAF-253H
Product Overview : Recombinant human BRAF (416-766) was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 63 kDa.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : BRAF-253H
Description : BRAF is a member of the RAF family that is activated by members of the Ras family upon growth factor-induced stimulation. Active Ras can induce heterodimerization of cRaf and BRAF and this may explain the observed cooperativity of cRaf and BRaf in cells responding to growth factor signals. Activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations result in a valine to glutamic acid change at residue 599 within the activation segment of B-RAF.
Source : Sf9 insect cells using baculovirus.
Sequence : 416-766.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : BRAF v-raf murine sarcoma viral oncogene homolog B1 [ Homo sapiens ]
Synonyms : v-raf murine sarcoma viral oncogene homolog B1; BRAF1; RAFB1; B-RAF1; FLJ95109; MGC126806; MGC138284; BRAF; B-Raf; 94 kDa B-raf protein; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf; EC 2.7.11.1; p94
Gene ID : 673
mRNA Refseq : NM_004333
Protein Refseq : NP_004324
MIM : 164757
UniProt ID : P15056
Chromosome Location : 7q34
Pathway : Acute myeloid leukemia; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Colorectal cancer; Endometrial cancer; ErbB signaling pathway; Focal adhesion; Glioma; Insulin signaling pathway; Long-term depression; Long-term potentiation; MAPK signaling pathway; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Progesterone-mediated oocyte maturation; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; Thyroid cancer; Vascular smooth muscle contraction; mTOR signaling pathway
Function : mitogen-activated protein kinase kinase binding; MAP kinase kinase kinase activity; protein heterodimerization activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; receptor signaling protein activity; ATP binding; metal ion binding; nucleotide binding; protein binding; transferase activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (1)

Ask a question
Please let us confirm whether or not the following kinase products marketed by your company are products applicable to the Cartagena Law in Japan.
If the product is used in Japan and falls under the Cartagena Law, it needs to be controlled appropriately.
BRAF-550H 04/15/2023

This protein is not a living modified organism, so it does not apply to the Cartagena Law in Japan. No worries.

Customer Reviews (0)

Write a review

Ask a Question for All BRAF Products

Required fields are marked with *

My Review for All BRAF Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends