Expand Expand| Cat. No. : | KIT-256H |
| Product Overview : | Recombinant human c-KIT (544-end, V654A) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 73 kDa. |
| Description : | c-KIT is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. c-KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in c-KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed curbing neoplastic mast cell growth. |
| Source : | Sf9 insect cells using baculovirus. |
| Sequence : | 544-end; V654A. |
| Applications : | Kinase Assay, Western Blot. |
| Storage And Stability : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Gene Name : | KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [ Homo sapiens ] |
| Synonyms : | KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT; SCFR; C-Kit; CD117; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; soluble KIT variant 1; mast/stem cell growth factor receptor; proto-oncogene tyrosine-protein kinase Kit; EC 2.7.10.1 |
| Gene ID : | 3815 |
| mRNA Refseq : | NM_000222 |
| Protein Refseq : | NP_000213 |
| MIM : | 164920 |
| UniProt ID : | P10721 |
| Chromosome Location : | 4q11-q12 |
| Pathway : | Acute myeloid leukemia; Cytokine-cytokine receptor interaction; Endocytosis; Hematopoietic cell lineage; Melanogenesis; Pathways in cancer |
| Function : | ATP binding; nucleotide binding; protein binding; receptor signaling protein tyrosine kinase activity; stem cell factor receptor activity; transferase activity |
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