"AURKB" Related Products


Recombinant Human Aurora Kinase B, GST-tagged, Active

Cat. No. : AURKB-247H
Product Overview : Recombinant full-length human AURORAB was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 68 kDa.
Description : AURORA B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. AURORA B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURORA B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92. This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. AURORA B has been identified as a target for the development of new anticancer agents since inhibition of AURORA B gives rise to the more pronounced antiproliferative phenotype.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : AURKB aurora kinase B [ Homo sapiens ]
Synonyms : AURKB; aurora kinase B ; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; aurkb-sv1; aurkb-sv2; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; serine/threonine kinase 12; EC; Aurora- and Ipl1-like midbody-associated protein 1; Aurora-related kinase 2; Aurora/IPL1-related kinase 2
Gene ID : 9212
mRNA Refseq : NM_004217
Protein Refseq : NP_004208
MIM : 604970
UniProt ID : Q96GD4
Chromosome Location : 17p13.1
Function : ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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