Recombinant Human Aurora Kinase B, GST-tagged, Active
Cat.No. : | AURKB-247H |
Product Overview : | Recombinant full-length human AURORAB was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 68 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | AURKB-247H |
Description : | AURORA B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. AURORA B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURORA B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92. This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. AURORA B has been identified as a target for the development of new anticancer agents since inhibition of AURORA B gives rise to the more pronounced antiproliferative phenotype. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | AURKB aurora kinase B [ Homo sapiens ] |
Synonyms : | AURKB; aurora kinase B ; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; aurkb-sv1; aurkb-sv2; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; serine/threonine kinase 12; EC 2.7.11.1; Aurora- and Ipl1-like midbody-associated protein 1; Aurora-related kinase 2; Aurora/IPL1-related kinase 2 |
Gene ID : | 9212 |
mRNA Refseq : | NM_004217 |
Protein Refseq : | NP_004208 |
MIM : | 604970 |
UniProt ID : | Q96GD4 |
Chromosome Location : | 17p13.1 |
Function : | ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
AURKB-909M | Recombinant Mouse AURKB Protein, His (Fc)-Avi-tagged | +Inquiry |
AURKB-1113H | Recombinant Human AURKB Protein (A2-A344), GST tagged | +Inquiry |
Aurkb-1789M | Recombinant Mouse Aurkb Protein, Myc/DDK-tagged | +Inquiry |
AURKB-1112H | Recombinant Human AURKB Protein (A2-A344), Tag Free | +Inquiry |
Aurkb-279R | Recombinant Rat Aurkb Protein, His-tagged | +Inquiry |
◆ Lysates | ||
AURKB-8560HCL | Recombinant Human AURKB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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