Recombinant Human NEK6, GST-tagged, Active NEK6-370H

Recombinant Human NEK6, GST-tagged, Active

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Recombinant Human NEK6, GST-tagged, Active

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Cat. No. : NEK6-370H
Product Overview : Recombinant full-length human NEK6 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=63 kDa.
Description : NEK6 is a serine/threonine kinase that is a member of the Nek family of protein kinases that share an amino-terminal catalytic domain related to NIMA family. Nek6 is a nuclear and cytoplasmic kinase that is required for mitotic progression of human cells. Nek6 is phosphorylated and activated during M phase of the cell cycle. Inhibition of Nek6 function by either overexpression of an inactive Nek6 mutant or elimination of endogenous Nek6 by siRNA arrests cells in M phase and triggers apoptosis.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : NEK6 NIMA (never in mitosis gene a)-related kinase 6 [ Homo sapiens ]
Synonyms : NEK6; NIMA (never in mitosis gene a)-related kinase 6; SID6-1512; NIMA-related kinase 6; OTTHUMP00000022097; putative serine-threonine protein kinase; EC 2.7.11.1
Gene ID : 10783
mRNA Refseq : NM_001145001
Protein Refseq : NP_001138473
MIM : 604043
UniProt ID : P51955
Chromosome Location : 9q33.3-q34.11
Function : ATP binding; magnesium ion binding; nucleotide binding; protein phosphatase binding; protein serine/threonine kinase activity; transferase activity; protein serine/threonine kinase activity; signal transducer activity

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