Cat. No. :	RPS6KB2-377H
Product Overview :	Recombinant full-length human RPS6KB1 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=85 kDa.
Description :	P70S6Kb is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and is activated by mitogenic stimuli, including growth factors, cytokines, and phorbol esters. p70S6Kb contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. PI3 kinase pathway and mTOR are involved in the activation of p70S6Kb but other pathways can also activate this target protein.
Source :	Sf9 insect cells using baculovirus.
Sequence :	Full-length.
Applications :	Kinase Assay, Western Blot.
Storage And Stability :	Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Name :	RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [ Homo sapiens ]
Synonyms :	RPS6KB2; ribosomal protein S6 kinase, 70kDa, polypeptide 2; KLS; SRK; S6K2; STK14B; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta; S6 kinase-related kinase; p70 ribosomal S6 kinase beta; serine/threonine-protein kinase 14 beta; EC 2.7.11.1
Gene ID :	6199
mRNA Refseq :	NM_003952
Protein Refseq :	NP_003943
MIM :	608939
UniProt ID :	Q9UBS0
Chromosome Location :	11q13.2
Pathway :	Acute myeloid leukemia; ErbB signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway; TGF-beta signaling pathway; mTOR signaling pathway; Signaling by NGF
Function :	ATP binding; nucleotide binding; protein binding; ribosomal protein S6 kinase activity; transferase activity

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