Recombinant Human RPS6KB2, GST-tagged, Active
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Cat. No. : | RPS6KB2-377H |
Product Overview : | Recombinant full-length human RPS6KB1 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=85 kDa. |
Description : | P70S6Kb is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and is activated by mitogenic stimuli, including growth factors, cytokines, and phorbol esters. p70S6Kb contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. PI3 kinase pathway and mTOR are involved in the activation of p70S6Kb but other pathways can also activate this target protein. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-lengt h. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [ Homo sapiens ] |
Synonyms : | RPS6KB2; ribosomal protein S6 kinase, 70kDa, polypeptide 2; KLS; SRK; S6K2; STK14B; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta; S6 kinase-related kinase; p70 ribosomal S6 kinase beta; serine/threonine-protein kinase 14 beta; EC 2.7.11.1 |
Gene ID : | 6199 |
mRNA Refseq : | NM_003952 |
Protein Refseq : | NP_003943 |
MIM : | 608939 |
UniProt ID : | Q9UBS0 |
Chromosome Location : | 11q13.2 |
Pathway : | Acute myeloid leukemia; ErbB signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway; TGF-beta signaling pathway; mTOR signaling pathway; Signaling by NGF |
Function : | ATP binding; nucleotide binding; protein binding; ribosomal protein S6 kinase activity; transferase activity |
◆ Recombinant Protein
Rps6kb2-5614M | Recombinant Mouse Rps6kb2 Protein, Myc/DDK-tagged | +Inquiry |
RPS6KB2-360H | Recombinant Human RPS6KB2 protein, His/MBP-tagged | +Inquiry |
RPS6KB2-2437H | Recombinant Human RPS6KB2, His-tagged | +Inquiry |
RPS6KB2-30618TH | Recombinant Human RPS6KB2 | +Inquiry |
RPS6KB2-5193H | Recombinant Human RPS6KB2 protein, GST-tagged | +Inquiry |
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◆ Lysates
RPS6KB2-2158HCL | Recombinant Human RPS6KB2 293 Cell Lysate | +Inquiry |
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RPS14 RPS27A RPS3 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RPS6KA6 RPS6KB1 RPS6KB2 RPS6 RPS15 RPS17 RPS19 RPS2 RPS23 RPS27 RPS5 RPS7 RPS6KA4 RPS11 RPS20 RPS28 RPS29 RPS4X RPS6KC1 RPS8 RPS9 RPS24 RPS13 RPS26 RPS27L RPS18 RPS19BP1 RPS21 RPS25 RPS6KL1 RPS4Y1 RPS3A RPS15A RPS10 RPS12 Rps16 RPS17L
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