Recombinant Human PIK3CB/PIK3R1, His-tagged, Active


Home / Products / Recombinant Proteins / Recombinant Human PIK3CB/PIK3R1, His-tagged, Active

Recombinant Human PIK3CB/PIK3R1, His-tagged, Active

PIK3CB Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat. No. : PIK3CB/PIK3R1-391H
Product Overview : Recombinant human full-length p110beta and human p85alpha were co-expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag on both proteins. MW=111 kDa (p110β), ~86 kDa (p85α).
Description : The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110β catalytic subunit (PIK3CB) plays a role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation. In animal model of prostate tumor formation induced by the tumor suppressor PTEN loss, ablation of p110β impedes tumorigenesis with a concomitant diminution of AKT phosphorylation.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-lengt h.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide [ Homo sapiens ],PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Homo sapiens ]
Synonyms : PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3K; PIK3C1; P110BETA; PI3KBETA; MGC133043; DKFZp779K1237; PtdIns-3-kinase p110; PI3-kinase p110 subunit beta; Phosphatidylinositol-4, 5-bisphosphate 3-kinase; catalytic subunit beta isoform; EC; PI3-kinase p110 subunit beta; PtdIns-3-kinase p110; PI3Kbeta; PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); p85; GRB1; p85-ALPHA
Gene ID : 5291,5295
mRNA Refseq : NM_006219,NM_181504
Protein Refseq : NP_006210,NP_852556
UniProt ID : P42338, P27986
Chromosome Location : 3q21, 5q13.1
MIM : 602925,171833
Pathway : Acute myeloid leukemia; Apoptosis; B cell receptor signaling pathway; Chemokine signaling pathway; Chronic myeloid leukemia; Colorectal cancer; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Glioma; Inositol phosphate metabolism; Insulin signaling pathway; Jak-STAT signaling pathway; Leukocyte transendothelial migration; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Phosphatidylinositol signaling; Progesterone-mediated oocyte maturation; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus; VEGF signaling pathway; mTOR signaling pathway
Function : 1-phosphatidylinositol-3-kinase activity; ATP binding; inositol or phosphatidylinositol kinase activity; insulin receptor substrate binding; nucleotide binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotransferase activity, alcohol group as acceptor; transferase activity; ErbB-3 class receptor binding

Online Inquiry

  • Note: There will be extra charge for optional service!
  • Verification Code Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy