"PRKCZ" Related Products


Recombinant Human Protein Kinase C, Zeta, GST-tagged, Active

Cat. No. : PRKCZ-409H
Product Overview : Recombinant full-length human PRKCZ was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=93kDa.
Description : PKCζ is an atypical isoform of the PKC family. PKCζ is found in both particulate and soluble fractions and cannot be activated by phorbol ester. Overexpression of PKCζ and subsequent phorbol ester treatment abolished phorbol ester-induced reduction in cell proliferation. Overexpression of PKCζ also potentiates phorbol ester-induced mitogen-activated protein (MAP) kinase activation in a PKC-dependent manner. PKCζ is an upstream modulator of p70S6K, an important regulator of cell proliferation.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : PRKCZ protein kinase C, zeta [ Homo sapiens ]
Synonyms : PRKCZ; protein kinase C, zeta; PKC2; PKC-ZETA; EC; nPKC-zeta; Protein kinase C zeta type
Gene ID : 5590
mRNA Refseq : NM_001033581
Protein Refseq : NP_001028753
MIM : 176982
UniProt ID : Q05513
Chromosome Location : 1p36.33-p36.2
Pathway : Chemokine signaling pathway; Endocytosis; Insulin signaling pathway; Tight junction; Type II diabetes mellitus
Function : ATP binding; insulin receptor substrate binding; metal ion binding; nucleotide binding; phospholipase binding; potassium channel regulator activity; protein kinase C activity; transferase activity; zinc ion binding

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