Recombinant Human RIPK2, GST-tagged, Active

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Recombinant Human RIPK2, GST-tagged, Active

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Cat. No. : RIPK2-418H
Product Overview : Recombinant human RIPK2 (1-299) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=59kDa.
Description : RIPK2 (RIP2; RICK) is a death domain-containing protein kinase encoding a predicted 540-amino acid protein which contains an N-terminal serine/threonine kinase catalytic domain and a C-terminal caspase activation and recruitment domain. RIPK2 is thought to regulate apoptosis induced by the FAS receptor pathway. RIPK2 has been shown to specifically interact with the CARD of ICE/caspase-1 and this interaction correlates with the processing of pro-caspase-1 and the formation of the active caspase-1 p20.
Source : Sf9 insect cells using baculovirus.
Sequence : 1-299.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : RIPK2 receptor-interacting serine-threonine kinase 2 [ Homo sapiens ]
Synonyms : RIPK2; receptor-interacting serine-threonine kinase 2; CARD-carrying kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; growth-inhibiting gene 30; receptor interacting protein 2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; EC 2.7.11.1
Gene ID : 8767
mRNA Refseq : NM_003821
Protein Refseq : NP_003812
MIM : 603455
UniProt ID : O43353
Chromosome Location : 8q21
Pathway : NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Signaling in Immune system; Signalling by NGF
Function : ATP binding; CARD domain binding; LIM domain binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; signal transducer activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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