Recombinant Human TANK-binding Kinase 1, GST-tagged, Active

• Cat.No.: TBK1-443H
• Product Overview: Recombinant full-length human TBK1 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 105 kDa.

Specification

• Cat. No.: TBK1-443H
• Description: TBK1, also known as NAK or NFkB-activating kinase, is an upstream protein kinase that can phosphorylate and activate the IkB kinases. Activation of IkB kinases allows the phosphorylation of IkB protein which is then degraded via the ubiquitination pathway. This mechanism allows the activation of the NFkB transcriptional complex. TBK1 is a specific upstream regulator of IkB kinases and can also interact and the IkB protein TANK. TBK1 is a component of the virus-activated kinase that phosphorylate IRF3 and IRF7 allowing their dimerization and translocation to the nucleus, where they induce transcription of interferon.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Publication:
  Quantitation of the Dynamic Profiles of the Innate Immune Response Using Multiplex Selected Reaction Monitoring–Mass Spectrometry (2013)

Gene Information

• Gene Name: TBK1 TANK-binding kinase 1 [ Homo sapiens ]
• Synonyms: TBK1; TANK-binding kinase 1; NAK; T2K; FLJ11330; NF-kB-activating kinase; EC 2.7.11.1; NF-kappa-B-activating kinase; Serine/threonine-protein kinase TBK1
• Gene ID: 29110
• mRNA Refseq: NM_013254
• Protein Refseq: NP_037386
• MIM: 604834
• UniProt ID: Q9UHD2
• Chromosome Location: 12q14.1
• Pathway: RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity