Recombinant Human TGFBR2, GST-tagged, Active

• Cat.No.: TGFBR2-444H
• Product Overview: Recombinant human TGFbetaR2 (190-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 68 kDa.

Specification

• Cat. No.: TGFBR2-444H
• Description: TGFβR2 is a member of the TGFβ receptor subfamily and is a ser/thr protein kinase. TGFβR2-induced protein phosphorylation plays a key role in signal transduction that leads to mitogenic responses. The TGFβR2 receptor transmits signals from the cell surface to the nucleus and provides instructions for making transforming growth factor (TGF)-beta type II receptor. Mutations in TGFβR2 gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 190-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: TGFBR2 transforming growth factor, beta receptor II (70/80kDa) [ Homo sapiens ]
• Synonyms: TGFBR2; transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; EC 2.7.11.30
• Gene ID: 7048
• mRNA Refseq: NM_001024847
• Protein Refseq: NP_001020018
• MIM: 190182
• UniProt ID: P37173
• Chromosome Location: 3p22
• Pathway: Adherens junction; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; MAPK signaling pathway; Pancreatic cancer; TGF-beta signaling pathway; Signaling by TGF beta
• Function: ATP binding; SMAD binding; glycosaminoglycan binding; magnesium ion binding; manganese ion binding; protein heterodimerization activity; receptor activity; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type II; type I transforming growth factor beta receptor binding