Cat. No.:	TEK-445H
Product Overview:	Recombinant human TIE 2 (771-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 61 kDa.
Description:	TIE 2 or TEK is a receptor tyrosine kinase that is expressed principally on vascular endothelium. Disrupting TIE 2 function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TIE 2 receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TIE 2 kinase domain and are part of the cellular responses that mediate TIE 2 function. TIE 2 expression is upregulated in the endothelium of vascular "hot spots" in human breast cancer specimens. However, TIE 2 is also overexpressed in areas of active angiogenesis in normal tissues.
Source:	Sf9 insect cells using baculovirus.
Sequence:	771-end.
Applications:	Kinase Assay, Western Blot.
Storage And Stability:	Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Name:	TEK TEK tyrosine kinase, endothelial [ Homo sapiens ]
Synonyms:	TEK; TEK tyrosine kinase, endothelial; TIE2; VMCM; TIE-2; VMCM1; CD202B; soluble TIE2 variant 1; soluble TIE2 variant 2; p140 TEK
Gene ID:	7010
mRNA Refseq:	NM_000459
Protein Refseq:	NP_000450
MIM:	600221
UniProt ID:	Q02763
Chromosome Location:	9p21
Pathway:	Hemostasis; Signaling in Immune system
Function:	ATP binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

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