Recombinant Human Dual Specificity Phosphatase 22, GST-tagged, Active DUSP22-459H

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Recombinant Human Dual Specificity Phosphatase 22, GST-tagged, Active

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Cat. No. :	DUSP22-459H
Product Overview :	Recombinant full length human DUSP22 was expressed in E.coli cells using a N-terminal GST tag. MW = 43 kDa.
Description :	Dual specificity phosphatases (DUSP) family, which can dephosphorylate both phosphoserine/threonine and phosphotyrosine residues, comprise of two subgroups: "typical" DUSP (include 11 MKPs that dephosphorylate the mitogen-activated protein kinases Erk, Jnk, and p38 at their dually phosphorylated TXY activation loop motif) and "atypical" DUSP (include 8 enzymes that lack specific MAP kinase-targeting motifs and tend to be much smaller proteins, which are less than 250 amino acid residues). DUSP22, also called JKAP, JSP1 and MKPX plays a role in various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling.
Source :	E.coli.
Sequence :	Full length.
Applications :	Phosphatase Assay, Western Blot.
Storage And Stability :	Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1wrm. :

Gene Name :	DUSP22 dual specificity phosphatase 22 [ Homo sapiens ]
Synonyms :	dual specificity phosphatase 22; VHX; JKAP; JSP1; MKPX; LMWDSP2; FLJ35864; DUSP22; JNK-stimulating phosphatase 1; mitogen-activated protein kinase phosphatase x; homolog of mouse dual specificity phosphatase LMW-DSP2; EC 3.1.3.48,EC 3.1.3.16; JSP-1; LMW-DSP2; OTTHUMP00000015938; JNK-stimulatory phosphatase-1; Mitogen-activated protein kinase phosphatase x
Gene ID :	56940
mRNA Refseq :	NM_020185
Protein Refseq :	NP_064570
UniProt ID :	Q9NRW4
Chromosome Location :	6p25.3
Function :	hydrolase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity