Recombinant Human Dual Specificity Phosphatase 22, GST-tagged, Active


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Recombinant Human Dual Specificity Phosphatase 22, GST-tagged, Active

DUSP22 Related Products

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Cat. No. : DUSP22-459H
Product Overview : Recombinant full length human DUSP22 was expressed in E.coli cells using a N-terminal GST tag. MW = 43 kDa.
Description : Dual specificity phosphatases (DUSP) family, which can dephosphorylate both phosphoserine/threonine and phosphotyrosine residues, comprise of two subgroups: "typical" DUSP (include 11 MKPs that dephosphorylate the mitogen-activated protein kinases Erk, Jnk, and p38 at their dually phosphorylated TXY activation loop motif) and "atypical" DUSP (include 8 enzymes that lack specific MAP kinase-targeting motifs and tend to be much smaller proteins, which are less than 250 amino acid residues). DUSP22, also called JKAP, JSP1 and MKPX plays a role in various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling.
Source : E.coli.
Sequence : Full length.
Applications : Phosphatase Assay, Western Blot.
Storage And Stability : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1wrm. :

Gene Name : DUSP22 dual specificity phosphatase 22 [ Homo sapiens ]
Synonyms : dual specificity phosphatase 22; VHX; JKAP; JSP1; MKPX; LMWDSP2; FLJ35864; DUSP22; JNK-stimulating phosphatase 1; mitogen-activated protein kinase phosphatase x; homolog of mouse dual specificity phosphatase LMW-DSP2; EC,EC; JSP-1; LMW-DSP2; OTTHUMP00000015938; JNK-stimulatory phosphatase-1; Mitogen-activated protein kinase phosphatase x
Gene ID : 56940
mRNA Refseq : NM_020185
Protein Refseq : NP_064570
UniProt ID : Q9NRW4
Chromosome Location : 6p25.3
Function : hydrolase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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