"PTPN7" Related Products

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Recombinant Human PTPN7,GST-tagged,Active

Cat. No. : PTPN7-466H
Product Overview : Recombinant human full length PTPN7 was expressed inE.colicells using a N-terminal GST tag. MW=67kDa.
Description : PTPN7 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN7 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway.
Source : E.coli.
Sequence : Full length.
Applications : Phosphatase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1zc0. :

Gene Name : PTPN7 protein tyrosine phosphatase, non-receptor type 7 [ Homo sapiens ]
Synonyms : PTPN7; protein tyrosine phosphatase, non-receptor type 7; EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase LC-PTP; LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP; Tyrosine-protein phosphatase non-receptor type 7
Gene ID : 5778
mRNA Refseq : NM_002832
Protein Refseq : NP_002823
UniProt ID : P35236
Chromosome Location : 1q32.1
MIM : 176889
Pathway : MAPK signaling pathway
Function : hydrolase activity; protein binding; protein tyrosine phosphatase activity

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