"PDE3A" Related Products

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Recombinant Human PDE3A, GST-tagged, Active

Cat. No.: PDE3A-473H
Product Overview: Recombinanthuman PDE3A (669-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=84kDa.
Description: PDE3A is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE3A has high affinity for both cAMP and cGMP and shows competitive inhibition of the cAMP hydrolytic activity by cGMP. Deletion of the N-terminus of PDE3A enhances the hydrolysis of cGMP relative to cAMP suggesting that the role of divergent N-termini of various PDEs could be to exert substrate specificity.
Source: Sf9 insect cells using baculovirus.
Sequence: 669-end.
Applications: PDE Assay.
Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
22q13.33: 12p12
Gene Name: PDE3A phosphodiesterase 3A, cGMP-inhibited [ Homo sapiens ]
Synonyms: PDE3A; phosphodiesterase 3A, calmodulin-dependent; cGMP-inhibited 3",5"-cyclic phosphodiesterase A; cyclic GMP inhibited phosphodiesterase A; phosphodiesterase 3A; CGI-PDE; EC 3.1.4.17
Gene ID: 5139
mRNA Refseq: NM_000921
Protein Refseq: NP_000912
MIM: 123805
UniProt ID: Q14432
Pathway: Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR; Insulin signaling pathway
Function: 3",5"-cyclic-AMP phosphodiesterase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; hydrolase activity

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