Recombinant Human PDE4C, GST-tagged, Active

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Recombinant Human PDE4C, GST-tagged, Active

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Cat. No. : PDE4C-477H
Product Overview : Recombinanthuman PDE4C (287-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=75kDa.
Description : PDE4C is a member of the phosphodiesterase (PDE) family that is cAMP-specific and has homology to the "dunce" gene of Drosophila. The "dunce" gene is one of several genes critical for normal learning and memory in the fly. Homozygous mutations in "dunce" cause defective short-term memory and behavioral defects. PDE4C is assigned to human chromosome 19 by Southern analyses while in situ hybridization localized the PDE4C gene to 19p13.1.
Source : Sf9 insect cells using baculovirus.
Sequence : 287-end.
Applications : PDE Assay.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
22q13.33 : 19p13.11
Gene Name : PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) [ Homo sapiens ]
Synonyms : PDE4C; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); DPDE1; MGC126222; phosphodiesterase 4C; EC 3.1.4.17
Gene ID : 5143
mRNA Refseq : NM_000923
Protein Refseq : NP_000914
MIM : 600128
UniProt ID : Q08493
Pathway : Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR
Function : 3",5"-cyclic-AMP phosphodiesterase activity; hydrolase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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