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Recombinant Human ABCF1, His-tagged

Cat.No. : ABCF1-26041TH
Product Overview : Recombinant fragment, corresponding to amino acids 474-807 of Human ABCF1 isoform 2, with a N terminal His tag; predicted MWt 39 kDa:
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  • Gene Information
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Description : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process.
Conjugation : HIS
Source : E. coli
Tissue specificity : Ubiquitous.
Form : Lyophilised:Reconstitution with 95 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : DDVCTDIIHLDAQRLHYYRGNYMTF KKMYQQKQKELLKQY EKQEKKLKELKAGGKSTKQAEKQTK EALTRKQQKCRRK NQDEESQEAPELLKRPKEYTVRFTF PDPPPLSPPVLGL HGVTFGYQGQKPLFKNLDFGIDMDS RICIVGPNGVGKSTL LLLLTGKLTPTHGEMRKNHRLKIGF FNQQYAEQLRMEE TPTEYLQRGFNLPYQDARKCLGRFG LESHAHTIQICKL SGGQKARVVFAELACREPDVLILDE PTNNLDIESIDALGEAINEYKGAVI VVSHDARLITETNCQLWVVEEQSVS QID GDFEDYKREVLEALGEVMVSRPRE
Sequence Similarities : Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.Contains 2 ABC transporter domains.
Gene Name : ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 [ Homo sapiens ]
Official Symbol : ABCF1
Synonyms : ABCF1; ATP-binding cassette, sub-family F (GCN20), member 1; ABC50; ATP-binding cassette sub-family F member 1; EST123147;
Gene ID : 23
mRNA Refseq : NM_001025091
Protein Refseq : NP_001020262
MIM : 603429
Uniprot ID : Q8NE71
Chromosome Location : 6p21.33
Function : ATP binding; ATP binding; ATPase activity; nucleotide binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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Are there any known genetic or epigenetic factors that influence ABCF1 expression or activity? 10/27/2021

It is possible that genetic variations, such as single nucleotide polymorphisms (SNPs) or epigenetic modifications, could potentially impact ABCF1 expression or function. 

How do domains of ABCF1 contribute to its function in translation initiation? 07/17/2021

The ABC domain is involved in ATP binding and hydrolysis, which provides the energy required for ABCF1's function in translation initiation. The NBDs are essential for the interaction of ABCF1 with other proteins and RNA molecules involved in translation initiation.

What are the cellular consequences of ABCF1 deficiency or depletion? 03/06/2021

It is expected that disruption of ABCF1 function could lead to defects in translation initiation and potentially impact overall protein synthesis.

Does ABCF1 play a role in protein synthesis or translation regulation? 09/29/2020

Yes, ABCF1 does play a role in protein synthesis and translation regulation. It is involved in the scanning process during translation initiation, ensuring accurate selection of the start codon and proper assembly of the translation initiation complex

What is the cellular function of ABCF1 and in which cellular processes does it participate? 06/17/2020

The cellular function of ABCF1 is associated with its involvement in translation initiation. It participates in the scanning process of ribosomes during translation initiation, ensuring the selection of the appropriate start codon on mRNA and facilitating the assembly of the translation initiation complex

Is there any evidence to suggest a role for ABCF1 in the development or progression of cancer? 06/17/2020

ABCF1 may be dysregulated or aberrantly expressed in certain cancers, including breast cancer and gastric cancer. 

Does ABCF1 exhibit any tissue-specific expression patterns? 05/28/2020

ABCF1 is generally expressed in various tissues and cell types, suggesting a broad expression profile.

Are there any known diseases or conditions where ABCF1 dysregulation has been implicated? 04/20/2020

Given its role in translation initiation, it is possible that dysregulation of ABCF1 could have implications for protein synthesis and potentially impact cellular processes related to translation

 Is ABCF1 regulated by any specific signaling pathways or cellular cues? 12/05/2019

It is plausible that cellular signaling pathways involved in translation regulation, stress responses, or other cellular processes could potentially modulate ABCF1 activity. 

Are there any post-translational modifications known to impact ABCF1 function or activity? 09/17/2019

It is plausible that post-translational modifications such as phosphorylation, acetylation, or ubiquitination could potentially regulate ABCF1. These modifications might influence its interaction with other proteins or RNA molecules, or impact its localization or activity.

What are the structural features or domains of ABCF1? 05/12/2019

The structural features or domains of ABCF1 that contribute to its function in translation initiation include the ATP-binding cassette (ABC) domain and the nucleotide-binding domains (NBDs)

Are there any specific diseases or conditions associated with ABCF1 dysfunction? 04/14/2019

Given its role in translation initiation, it is possible that dysregulation or malfunction of ABCF1 could have implications for protein synthesis and potentially impact cellular processes related to translation

Are there any specific regulatory mechanisms that control the activity or localization of ABCF1 within the cell? 11/15/2018

It is likely that post-translational modifications, protein-protein interactions, and potential signaling pathways could influence ABCF1 activity or its subcellular localization.

What animal models are commonly used to study ABCF1 function? 11/18/2017

Knockout mouse models, such as ABCF1-deficient mice, have been generated to investigate the physiological role of ABCF1 in vivo

Is ABCF1 involved in any specialized translation processes, such as translation of specific subsets of mRNAs? 04/20/2017

ABCF1's involvement in specialized translation processes, such as translation of specific subsets of mRNAs.

Are there any known interacting partners or binding partners of ABCF1? 01/15/2017

It interacts with eukaryotic initiation factors, such as eIF3, and is also associated with other proteins in the translation initiation complex. These interactions contribute to the regulation and coordination of translation initiation processes.

Does ABCF1 play a role in cellular stress responses or in the regulation of stress granules? 09/01/2016

stress granules are dynamic cytoplasmic aggregates that form during cellular stress, and as ABCF1 is involved in translation initiation, it is possible that it could play a role in stress granule formation or regulation in response to certain stress conditions. 

Does ABCF1 interact with any RNA-binding proteins or RNA molecules? 06/26/2016

ABCF1 has been shown to interact with RNA molecules, particularly during translation initiation. It interacts with specific regions of mRNA, including the 5' untranslated region (UTR), facilitating the scanning process of ribosomes during translation initiation.

 Are there any known mechanisms for the subcellular localization of ABCF1? 05/07/2016

It is known to be predominantly localized in the cytoplasm, possibly associated with ribosomes. The presence of certain localization signals or interacting proteins may contribute to its subcellular distribution

Are there any cell culture system are commonly used to study ABCF1 function? 04/25/2016

Cell culture systems, including both primary cells and established cell lines, are commonly used to study the molecular mechanisms and functional consequences of ABCF1 manipulation.

Customer Reviews (3)

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Reviews
11/03/2017

    The company showed great attention to my questions and requirements.

    06/24/2017

      Using the protein resulted in robust and reproducible data."

      05/29/2016

         Its quality, reliability, and the support provided by the company made it well worth the investment in my research

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