Recombinant Human ABCF1, His-tagged
Cat.No. : | ABCF1-26041TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 474-807 of Human ABCF1 isoform 2, with a N terminal His tag; predicted MWt 39 kDa: |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. |
Conjugation : | HIS |
Source : | E. coli |
Tissue specificity : | Ubiquitous. |
Form : | Lyophilised:Reconstitution with 95 μl aqua dest. |
Storage buffer : | Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | DDVCTDIIHLDAQRLHYYRGNYMTF KKMYQQKQKELLKQY EKQEKKLKELKAGGKSTKQAEKQTK EALTRKQQKCRRK NQDEESQEAPELLKRPKEYTVRFTF PDPPPLSPPVLGL HGVTFGYQGQKPLFKNLDFGIDMDS RICIVGPNGVGKSTL LLLLTGKLTPTHGEMRKNHRLKIGF FNQQYAEQLRMEE TPTEYLQRGFNLPYQDARKCLGRFG LESHAHTIQICKL SGGQKARVVFAELACREPDVLILDE PTNNLDIESIDALGEAINEYKGAVI VVSHDARLITETNCQLWVVEEQSVS QID GDFEDYKREVLEALGEVMVSRPRE |
Sequence Similarities : | Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.Contains 2 ABC transporter domains. |
Gene Name : | ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 [ Homo sapiens ] |
Official Symbol : | ABCF1 |
Synonyms : | ABCF1; ATP-binding cassette, sub-family F (GCN20), member 1; ABC50; ATP-binding cassette sub-family F member 1; EST123147; |
Gene ID : | 23 |
mRNA Refseq : | NM_001025091 |
Protein Refseq : | NP_001020262 |
MIM : | 603429 |
Uniprot ID : | Q8NE71 |
Chromosome Location : | 6p21.33 |
Function : | ATP binding; ATP binding; ATPase activity; nucleotide binding; protein binding; |
Products Types
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionIt is possible that genetic variations, such as single nucleotide polymorphisms (SNPs) or epigenetic modifications, could potentially impact ABCF1 expression or function.
The ABC domain is involved in ATP binding and hydrolysis, which provides the energy required for ABCF1's function in translation initiation. The NBDs are essential for the interaction of ABCF1 with other proteins and RNA molecules involved in translation initiation.
It is expected that disruption of ABCF1 function could lead to defects in translation initiation and potentially impact overall protein synthesis.
Yes, ABCF1 does play a role in protein synthesis and translation regulation. It is involved in the scanning process during translation initiation, ensuring accurate selection of the start codon and proper assembly of the translation initiation complex
The cellular function of ABCF1 is associated with its involvement in translation initiation. It participates in the scanning process of ribosomes during translation initiation, ensuring the selection of the appropriate start codon on mRNA and facilitating the assembly of the translation initiation complex
ABCF1 may be dysregulated or aberrantly expressed in certain cancers, including breast cancer and gastric cancer.
ABCF1 is generally expressed in various tissues and cell types, suggesting a broad expression profile.
Given its role in translation initiation, it is possible that dysregulation of ABCF1 could have implications for protein synthesis and potentially impact cellular processes related to translation
It is plausible that cellular signaling pathways involved in translation regulation, stress responses, or other cellular processes could potentially modulate ABCF1 activity.
It is plausible that post-translational modifications such as phosphorylation, acetylation, or ubiquitination could potentially regulate ABCF1. These modifications might influence its interaction with other proteins or RNA molecules, or impact its localization or activity.
The structural features or domains of ABCF1 that contribute to its function in translation initiation include the ATP-binding cassette (ABC) domain and the nucleotide-binding domains (NBDs)
Given its role in translation initiation, it is possible that dysregulation or malfunction of ABCF1 could have implications for protein synthesis and potentially impact cellular processes related to translation
It is likely that post-translational modifications, protein-protein interactions, and potential signaling pathways could influence ABCF1 activity or its subcellular localization.
Knockout mouse models, such as ABCF1-deficient mice, have been generated to investigate the physiological role of ABCF1 in vivo
ABCF1's involvement in specialized translation processes, such as translation of specific subsets of mRNAs.
It interacts with eukaryotic initiation factors, such as eIF3, and is also associated with other proteins in the translation initiation complex. These interactions contribute to the regulation and coordination of translation initiation processes.
stress granules are dynamic cytoplasmic aggregates that form during cellular stress, and as ABCF1 is involved in translation initiation, it is possible that it could play a role in stress granule formation or regulation in response to certain stress conditions.
ABCF1 has been shown to interact with RNA molecules, particularly during translation initiation. It interacts with specific regions of mRNA, including the 5' untranslated region (UTR), facilitating the scanning process of ribosomes during translation initiation.
It is known to be predominantly localized in the cytoplasm, possibly associated with ribosomes. The presence of certain localization signals or interacting proteins may contribute to its subcellular distribution
Cell culture systems, including both primary cells and established cell lines, are commonly used to study the molecular mechanisms and functional consequences of ABCF1 manipulation.
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Using the protein resulted in robust and reproducible data."
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