Recombinant Human ACADVL, His-tagged

• Cat.No.: ACADVL-26050TH
• Product Overview: Recombinant full length Human ACADVL with an N terminal His tag; 636 amino acids including tag, MWt 68.5kDa.

Specification

• Description: The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Protein length: 615 amino acids
• Conjugation: HIS
• Molecular Weight: 68.500kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM EDTA, 1mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMAGGA AQLALDKSDSHPSDALTRKKPAKAE SKSFAVGMFKGQLTTDQVFPYPSVL NEEQTQFLKELVEPVSRFFEEVNDP AKNDALEMVEETTWQGLKELGAFGL QVPSELGGVGLCNTQYARLVEIVGM HDLGVGITLGAHQSIGFKGILLFGT KAQKEKYLPKLASGETVAAFCLTEP SSGSDAASIRTSAVPSPCGKYYTLN GSKLWISNGGLADIFTVFAKTPVTD PATGAVKEKITAFVVERGFGGITHG PPEKKMGIKASNTAEVFFDGVRVPS ENVLGEVGSGFKVAMHILNNGRFGM AAALAGTMRGIIAKAVDHATNRTQF GEKIHNFGLIQEKLARMVMLQYVTE SMAYMVSANMDQGATDFQIEAAISK IFGSEAAWKVTDECIQIMGGMGFMK EPGVERVLRDLRIFRIFEGTNDILR LFVALQGCMDKGKELSGLGSALKNP FGNAGLLLGEAGKQLRRRAGLGSGL SLSGLVHPELSRSGELAVRALEQFA TVVEAKLIKHKKGIVNEQFLLQRLA DGAIDLYAMVVVLSRASRSLSEGHP TAQHEKMLCDTWCIEAAARIREGMA ALQSDPWQQELYRNFKSISKALVER GGVVTSNPLGF
• Sequence Similarities: Belongs to the acyl-CoA dehydrogenase family.

Gene Information

• Gene Name: ACADVL acyl-CoA dehydrogenase, very long chain [ Homo sapiens ]
• Official Symbol: ACADVL
• Synonyms: ACADVL; acyl-CoA dehydrogenase, very long chain; acyl Coenzyme A dehydrogenase, very long chain; very long-chain specific acyl-CoA dehydrogenase, mitochondrial; ACAD6; LCACD; VLCAD
• Gene ID: 37
• mRNA Refseq: NM_000018
• Protein Refseq: NP_000009
• MIM: 609575
• Uniprot ID: P49748
• Chromosome Location: 17p13.1
• Pathway: Activation of Chaperones by IRE1alpha, organism-specific biosystem; Beta oxidation of palmitoyl-CoA to myristoyl-CoA, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Fatty Acid Beta Oxidation, organism-specific biosystem
• Function: acyl-CoA dehydrogenase activity; fatty-acyl-CoA binding; flavin adenine dinucleotide binding; long-chain-acyl-CoA dehydrogenase activity; very long-chain-acyl-CoA dehydrogenase activity