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Recombinant Human ACOX1

Cat.No.: ACOX1-26477TH
Product Overview: Recombinant full length Human ACOX1 with N-Terminal proprietary tag. Mol Wt 98.71 kDa inclusive of tag.
Description: The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein length: 660 amino acids
Molecular Weight: 98.710kDa inclusive of tags
Source: Wheat germ
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMI LNDPDFQHEDLNFLTRSQRYEVAVRKSAIMVKKMREFGIA DPDEIMWFKNFVHRGRPEPLDLHLGMFLPTLLHQATAEQQ ERFFMPAWNLEIIGTYAQTEMGHGTHLRGLETIATYDPET QEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCY GLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYL KMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVF VRSFLVGEAARALSKACTIAIRYSAVRHQSEMKPGEPEPQ ILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIG QGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHG YSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYD QVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSP ESLTEAYKLRAARLVEIAAKNLQKEVIHRKSKEVAWNLTS VDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQAVLRSLCL LYSLYGISQNAGDFLQGSIMTEPQITQVNQRVKELLTLIR SDAVALVDAFDFQDVTLGSVLGRYDGNVYENLFEWAKNSP LNKAEVHESYKHLKSLQSKL
Sequence Similarities: Belongs to the acyl-CoA oxidase family.
Gene Name: ACOX1 acyl-CoA oxidase 1, palmitoyl [ Homo sapiens ]
Official Symbol: ACOX1
Synonyms: ACOX1; acyl-CoA oxidase 1, palmitoyl; acyl Coenzyme A oxidase 1, palmitoyl; peroxisomal acyl-coenzyme A oxidase 1; PALMCOX;
Gene ID: 51
mRNA Refseq: NM_001185039
Protein Refseq: NP_001171968
MIM: 609751
Uniprot ID: Q15067
Chromosome Location: 17q25.1
Pathway: Beta-oxidation of very long chain fatty acids, organism-specific biosystem; Biosynthesis of unsaturated fatty acids, organism-specific biosystem; Biosynthesis of unsaturated fatty acids, conserved biosystem; Fatty acid metabolism, organism-specific biosystem; Fatty acid metabolism, conserved biosystem;
Function: acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; acyl-CoA oxidase activity; acyl-CoA oxidase activity; flavin adenine dinucleotide binding;

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