| Description : |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. |
| Conjugation : |
HIS |
| Source : |
E. coli |
| Tissue specificity : |
Expressed in both skeletal and cardiac muscle. |
| Form : |
Lyophilised:Reconstitution with 136 μl aqua dest. |
| Storage buffer : |
Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
| Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
QAETAANRICKVLAVNQENERLMEE YERLASELLEWIRRT IPWLENRTPEKTMQAMQKKLEDFRD YRRKHKPPKVQEK CQLEINFNTLQTKLRISNRPAFMPS EGKMVSDIAGAWQ RLEQAEKGYEEWLLNEIRRLERLEH LAEKFRQKASTHETW AYGKEQILLQKDYESASLTEVRALL RKHEAFESDLAAH QDRVEQIAAIAQELNELDYHDAVNV NDRCQKICDQWDR LGTLTQKRREALERMEKLLETIDQL HLEFAKRAAPFNN WMEGAMEDLQDMFIVHSIEEIQSLI TAHEQFKATLPEADG ERQSIMAIQNEVEKVIQSYNIRISS SNPYSTVTMDELR TKWDKVKQLVPIRDQSLQEELARQH ANERLRRQFAAQA NAIGPWIQNKMEEIARSSIQITGAL EDQMNQLKQYEHNIINYKNNIDKLE GDHQLIQEALVFDNKHTNYTMEHIR VGW ELLLTTIARTINEVETQILTRDAKG ITQEQMNEFRASF NHFDRRKNGLMDHEDFRACLISMGY DLGEAEFARIMTL VDPNGQGTVTFQSFIDFMTRETADT DTAEQVIASFRILAS DKPYILAEELRRELPPDQAQYCIKR MPAYSGPGSVPGA LDYAAFSS |
| Sequence Similarities : |
Belongs to the alpha-actinin family.Contains 1 actin-binding domain.Contains 2 CH (calponin-homology) domains.Contains 2 EF-hand domains.Contains 4 spectrin repeats. |
