Recombinant Human ACTN2, His-tagged ACTN2-31382TH

Specification
Gene Information
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Cat.No.:	ACTN2-31382TH
Product Overview:	Recombinant fragment, corresponding to amino acids 261-886 of Human Sarcomeric Alpha Actinin, with N terminal His tag, 626 amino acids, 72kDa, ,
Description:	Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.
Conjugation:	HIS
Source:	E. coli
Tissue specificity:	Expressed in both skeletal and cardiac muscle.
Form:	Lyophilised:Reconstitution with 136 μl aqua dest.
Storage buffer:	Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids:	QAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRT IPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEK CQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQ RLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETW AYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAH QDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR LGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNN WMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADG ERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELR TKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQA NAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGW ELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASF NHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTL VDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILAS DKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGA LDYAAFSS
Sequence Similarities:	Belongs to the alpha-actinin family.Contains 1 actin-binding domain.Contains 2 CH (calponin-homology) domains.Contains 2 EF-hand domains.Contains 4 spectrin repeats.

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Gene Name:	ACTN2 actinin, alpha 2 [ Homo sapiens ]
Official Symbol:	ACTN2
Synonyms:	ACTN2; actinin, alpha 2; alpha-actinin-2;
Gene ID:	88
mRNA Refseq:	NM_001103
Protein Refseq:	NP_001094
MIM:	102573
Uniprot ID:	P35609
Chromosome Location:	1q42-q43
Pathway:	Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem;
Function:	FATZ 1 binding; ZASP binding; actin binding; calcium ion binding; identical protein binding;